Requirement for B-lymphocyte alloantigen in the production of neutrophil migration inhibition factor from T lymphocytes (NIF-T).

Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is produced in response to mitogens as the result of cellular interactions between T and B lymphocytes. The requirement for B-cell alloantigen in this interaction process was indicated by (1) collaboration between peripheral blood T cells with various B lymphoblast cell lines but not with non-B lymphoblast cells for NIF-T production, (2) inhibition of NIF-T production by treating collaborating B lymphoblasts with B-cell specific antiserum, and (3) inhibition of NIF-T production by peripheral blood lypmphocytes in the presence of anti-B-cell antiserum and F(ab')2 with anti-B-cell specificity.