Literature DB >> 6991271

Synthesis, crystallization and properties of acetyl phenylalanyl lysine chloromethyl ketone: a potential inhibitor of serine proteases.

V V Murthy, T Laster.   

Abstract

A procedure for the synthesis of acetyl phenylalanyl lysine chloromethyl ketone is described. The chloromethyl ketone derivative is a noncompetitive inhibitor of trypsin (Ki = 5.9 x 10(-3) M).

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Year:  1980        PMID： 6991271     DOI： 10.1007/bf01975108

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

1.  Direct evidence for the presence of histidine in the active center of chymotrypsin.

Authors:  G SCHOELLMANN; E SHAW
Journal:  Biochemistry       Date:  1963 Mar-Apr       Impact factor: 3.162

2.  A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.

Authors:  B C HUMMEL
Journal:  Can J Biochem Physiol       Date:  1959-12

3.  The determination of enzyme inhibitor constants.

Authors:  M DIXON
Journal:  Biochem J       Date:  1953-08       Impact factor: 3.857

4.  The crystal and molecular structure of DIP-inhibited bovine trypsin at2.7Angstrom resolution.

Authors:  R M Stroud; L M Kay; R E Dickerson
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1972

5.  Further observations on substrate-derived chloromethyl ketones that inactivate trypsin.

Authors:  E Shaw; G Glover
Journal:  Arch Biochem Biophys       Date:  1970-08       Impact factor: 4.013

6.  Affinity labelling of proteinases with tryptic specificity by peptides with C-terminal lysine chloromethyl ketone.

Authors:  J R Coggins; W Kray; E Shaw
Journal:  Biochem J       Date:  1974-03       Impact factor: 3.857
  6 in total
  1 in total

1.  Rare manifestations of sarcoidosis.

Authors:  J G McPherson; C B Yeoh
Journal:  J Natl Med Assoc       Date:  1993-11       Impact factor: 1.798
  1 in total

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