Literature DB >> 6989360

The effect of nitrofurantoin on deoxyribonucleic acid synthesis in plant mitochondria.

S Palit, B B Goswami, D K Dube.   

Abstract

Nitrofurantoin (1-([(5-nitrofuran-2-yl)methylene]amino)imidazolidine-2,4-dione), a widely used drug and also a well-known bacterial mutagen, inhibits DNA synthesis in mitochondria from 48 h etiolated seedlings of Vigna sinensis (Linn.) Savi (snake bean). The effect appears at the level of the uptake of radioactive deoxynucleoside triphosphates by the plant mitochondria. Nitrofurantoin does not inhibit DNA synthesis in vitro by homogeneous Escherichia coli DNA polymerase I and DNA polymerase from avian-myeloblastosis virus. No specific nitroreductase activity could be detected in mitochondria.

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Year:  1980        PMID： 6989360      PMCID： PMC1161534          DOI： 10.1042/bj1860325

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  "Activation" of nitrofurazone in animal tissues.

Authors:  D R McCalla; A Reuvers; C Kaiser
Journal:  Biochem Pharmacol       Date:  1971-12       Impact factor: 5.858

2.  Erroneous base-pairing induced by a chemical carcinogen during DNA synthesis.

Authors:  M A Sirover; L A Loeb
Journal:  Nature       Date:  1974-11-29       Impact factor: 49.962

3.  Purification and detection of reverse transcriptase in viruses and cells.

Authors:  D L Kacian; S Spiegelman
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

4.  Inhibition of mitochondrial protein synthesis by nitrofurantoin in rat and goat liver.

Authors:  B B Goswami; S Chakrabarti; P Bhattacharyya; S N Sinha; B K Roy; P Raychoudhuri; D K Dube
Journal:  Biochem Pharmacol       Date:  1974-01-15       Impact factor: 5.858

5.  The action of nitrofurantoin: inhibition of growth of Escherichia coli K 12 and of IPTG-induced beta-galaotosidase synthesis.

Authors:  R Röschenthaler; P Kindler; P Herrlich; J Igbokwe
Journal:  Zentralbl Bakteriol Orig       Date:  1970

Review 6.  The biogenesis of mitochondria.

Authors:  M Ashwell; T S Work
Journal:  Annu Rev Biochem       Date:  1970       Impact factor: 23.643

7.  Enzymatic synthesis of deoxyribonucleic acid. XXVI. Physical and chemical studies of a homogeneous deoxyribonucleic acid polymerase.

Authors:  T M Jovin; P T Englund; L L Bertsch
Journal:  J Biol Chem       Date:  1969-06-10       Impact factor: 5.157

8.  Avian myeloblastosis virus DNA polymerase. Kinetic studies on the incorporation of noncomplementary nucleotides.

Authors:  N Battula; D Dube; L A Loeb
Journal:  J Biol Chem       Date:  1975-11-10       Impact factor: 5.157

Review 9.  Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.

Authors:  J McCann; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

10.  Protein synthesis in vitro in a system from plant mitochondria.

Authors:  B B Goswami; S Chakrabarti; D K Dube; S C Roy
Journal:  Biochem J       Date:  1973-07       Impact factor: 3.857
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