Literature DB >> 6989171

Treatment of osteoporosis with 1-alpha-hydroxycholecalciferol and calcium.

V Hoikka, E M Alhava, A Aro, P Karjalainen, V Rehnberg.   

Abstract

A double-blind comparative study of 1 alpha-OHD3 and placebo was performed on 37 patients with osteoporotic hip fracture without clinical osteomalacia. 1 alpha-OHD3, in a dose of 1 microgram/day together with 2.5 g CaCO3, did not heal osteoporosis as judged from determinations of bone mineral density and histomorphometric analyses during four months of treatment. However, 1 alpha-OHD3 seemed to have an effect on fracture healing as concluded from the posttreatment alkaline phosphatase level. Hypercalcemia was common, occurring in six out of 19 patients treated with 1 alpha-OHD3. It is concluded that treatment of osteoporosis with 1 alpha-OHD3 and calcium is ineffective and potentially dangerous because it frequently causes hypercalcemia.

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Year:  1980        PMID： 6989171     DOI： 10.1111/j.0954-6820.1980.tb09709.x

Source DB:  PubMed          Journal:  Acta Med Scand        ISSN： 0001-6101


  8 in total

1.  Prevention of post-menopausal bone loss with 1 alpha-hydroxy vitamin D3. A three-year prospective study.

Authors:  J M Pouilles; F Tremollieres; C Ribot
Journal:  Clin Rheumatol       Date:  1992-12       Impact factor: 2.980

2.  Treatment of osteoporosis with vitamin D.

Authors:  J A Kanis; E V McCloskey; D de Takats; J Bernard; D M Zhang
Journal:  Osteoporos Int       Date:  1997       Impact factor: 4.507

3.  Alfacalcidol and hypercalcaemia.

Authors:  M Ardron
Journal:  Br Med J (Clin Res Ed)       Date:  1987-01-10

Review 4.  Nutritional supplementation for hip fracture aftercare in older people.

Authors:  Alison Avenell; Toby O Smith; James P Curtain; Jenson Cs Mak; Phyo K Myint
Journal:  Cochrane Database Syst Rev       Date:  2016-11-30

5.  Vitamin D status and adult fracture healing.

Authors:  E A Gorter; P Krijnen; I B Schipper
Journal:  J Clin Orthop Trauma       Date:  2016-09-23

6.  Treatment of osteoporosis with vitamin D3.

Authors:  M Shiraki
Journal:  Osteoporos Int       Date:  1993       Impact factor: 4.507

7.  Prevention and treatment of osteopenia in the ovariectomized rat: effect of combined therapy with estrogens, 1-alpha vitamin D, and prednisolone.

Authors:  P Geusens; J Dequeker; J Nijs; A Verstraeten; E Bramm
Journal:  Calcif Tissue Int       Date:  1991-02       Impact factor: 4.333

8.  25-Hydroxycholecalciferol in experimental osteoporosis.

Authors:  M Carrozzo; R Pallante; F P Cantatore; F Lo Sasso; M D'Amore; V Pipitone
Journal:  Clin Rheumatol       Date:  1985-09       Impact factor: 2.980
  8 in total

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