| Literature DB >> 6988911 |
C Rose, S M Thorpe, J Løber, J L Daenfeldt, T Palshof, H T Mouridsen.
Abstract
Cytoplasmic oestrogen receptor (ER) determinations were performed in 59 postmenopausal patients with metastatic breast cancer. Fifty percent of the patients were found to be ER+. Forty patients were treated with tamoxifen (TAM) and 19 patients were treated with tamoxifen plus medroxyprogesterone acetate (MPA). The response rate of TAM-treated patients was 30% (12/40). Of the 21 ER+ patients, ten (48%) responded to therapy. The ER values of these patients were significantly higher than the ER values of nonresponders (P less than 0.01). No correlation could be found between the ER value and the duration of remission in TAM-treated patients.Entities:
Keywords: Biology; Breast Cancer; Cancer; Clinical Research; Contraception; Contraceptive Agents; Contraceptive Agents, Estrogen; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Diethylstilbestrol; Diseases; Endocrine System; Estrogens; Family Planning; Fertility Agents; Hormone Receptors; Hormones; Medroxyprogesterone Acetate; Membrane Proteins; Neoplasms; Physiology; Reproductive Control Agents; Research Methodology; Tamoxifen--therapeutic use
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Year: 1980 PMID： 6988911 DOI： 10.1007/978-3-642-81406-8_19
Source DB: PubMed Journal: Recent Results Cancer Res ISSN： 0080-0015