Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Uptake of 3H-GABA (gamma-aminobutyric acid) and 3H-leucine in the pancreatic islets and substantia nigra of the rat.

Literature DB >> 6987072

Uptake of 3H-GABA (gamma-aminobutyric acid) and 3H-leucine in the pancreatic islets and substantia nigra of the rat.

Abstract

Isolated pancreatic islets and thin slices of substantia nigra (SN) of the rat were incubated in a medium containing 3H-GABA or 3H-leucine to test the activity of both tissues in the uptake of those substances. Pancreatic islets showed a low uptake of both 3H-GABA and 3H-leucine, but SN had a high activity in the uptake of 3H-GABA, though not for 3H-leucine. This suggests that GABA contained at high levels in the pancreatic islets some functional role other than in neurotransmission as in the central nervous system (CNS).

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1980 PMID： 6987072 DOI： 10.1007/BF02004018

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

13 in total

1. Uptake and metabolism of gamma-aminobutyric acid by neurones and glial cells.

Authors: L L Iversen; J S Kelly
Journal: Biochem Pharmacol Date: 1975-05-01 Impact factor: 5.858

2. Microdetermination of free amino acids in pancreatic islets isolated from obese-hyperglycemic mice.

Authors: G Briel; E Gylfe; B Hellman; V Neuhoff
Journal: Acta Physiol Scand Date: 1972-02

3. On the source of GABA-containing terminals in the substantia nigra. Electron microscopic autoradiographic and biochemical studies.

Authors: T Hattori; P L McGeer; H C Fibiger; E G McGeer
Journal: Brain Res Date: 1973-05-17 Impact factor: 3.252

4. Autoradiographic identification of cerebral and cerebellar cortical neurons accumulating labeled gamma-aminobutyric acid ( 3 H-GABA).

Authors: T Hökfelt; A Ljungdahl
Journal: Exp Brain Res Date: 1972 Impact factor: 1.972

Review 2. The role of GABA in islet function.

Authors: D Walker Hagan; Sandra M Ferreira; Gustavo J Santos; Edward A Phelps
Journal: Front Endocrinol (Lausanne) Date: 2022-09-29 Impact factor: 6.055

2 in total

Uptake of 3H-GABA (gamma-aminobutyric acid) and 3H-leucine in the pancreatic islets and substantia nigra of the rat.

1. Uptake and metabolism of gamma-aminobutyric acid by neurones and glial cells.

2. Microdetermination of free amino acids in pancreatic islets isolated from obese-hyperglycemic mice.

3. On the source of GABA-containing terminals in the substantia nigra. Electron microscopic autoradiographic and biochemical studies.

4. Autoradiographic identification of cerebral and cerebellar cortical neurons accumulating labeled gamma-aminobutyric acid ( 3 H-GABA).

5. [Occurrence of gamma-aminobutyric acid and gamma-amino-beta-hydroxybutyric acid in animal tissues].

6. Glutamic acid decarboxylase and gamma-aminobutyric acid in mammalian kidney.

7. Method for the isolation of intact islets of Langerhans from the rat pancreas.

8. Uptake and release of -aminobutyric acid (GABA) in slices of substantia nigra of rat.

9. L-glutamic acid decarboxylase in non-neural tissues of the mouse.

10. High concentration of GABA and high glutamate decarboxylase activity in rat pancreatic islets and human insulinoma.

1. Autoradiographic studies of the gamma-aminobutyric acid (GABA) system in the rat pancreas.

Review 2. The role of GABA in islet function.