Literature DB >> 6986923

Circulating immunoglobulin-secreting cells in patients with plasma cell dyscrasia.

K Shimizu, T Murate, A Kunii.   

Abstract

Immunoglobulin-secreting cells (ISC) in peripheral blood mononuclear cells (PBM) isolated from patients with plasma cell dyscrasia of various stages were studied using reverse hemolytic plaque assay. Normal healthy individuals contained 35 +/- 16 ISC/10(5) PBM. Aleukemic or subleukemic patients with overt myeloma contained 825 +/- 713 ISC, whereas leukemic patients contained 12,675 +/- 2520 ISC. Patients of premyelomatous stage, however, contained ISC/10(5) PBM of normal range. The relationship between ISC and clinical stage or laboratory data is discussed.

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Year:  1980        PMID： 6986923

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  6 in total

1.  Antigen stimulated IgM secretion by circulating B lymphocytes in patients with benign and malignant IgG gammopathy. Relationship to stage of disease.

Authors:  S Pollack; R Katz; I Tatarsky; A Carter
Journal:  Clin Exp Immunol       Date:  1989-01       Impact factor: 4.330

2.  Severe deficiency of B lymphocytes in peripheral blood from multiple myeloma patients.

Authors:  L M Pilarski; M J Mant; B A Ruether; A Belch
Journal:  J Clin Invest       Date:  1984-10       Impact factor: 14.808

3.  Detection and identification of serum monoclonal immunoglobulin by immunoisoelectric focusing. Limits of sensitivity and use during relapse of multiple myeloma.

Authors:  D Sinclair; D S Kumararatne; D Stott
Journal:  J Clin Pathol       Date:  1984-03       Impact factor: 3.411

4.  Immunoglobulin secretion by peripheral blood and bone marrow B cells in patients with multiple myeloma. Studies by the reverse haemolytic plaque assay.

Authors:  F Dammacco; A Vacca; E Altomare; N Campobasso
Journal:  Clin Exp Immunol       Date:  1984-09       Impact factor: 4.330

5.  Delay and not deficiency in cap formation of peripheral blood B cells in patients with multiple myeloma.

Authors:  X G Zhang; B Klein; C Duperray; J Brochier; R Bataille
Journal:  J Clin Immunol       Date:  1988-07       Impact factor: 8.317

6.  Differentiation of benign monoclonal gammopathy and smouldering multiple myeloma from frank myeloma.

Authors:  K Shimizu; K Ohnishi; A Kunii
Journal:  Clin Exp Immunol       Date:  1982-12       Impact factor: 4.330
  6 in total

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