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Literature DB >> 6986652

Insulin binding sites localized to nerve terminals in rat median eminence and arcuate nucleus.

M van Houten, B I Posner, B M Kopriwa, J R Brawer.

Abstract

Specific binding sites for blood-borne insulin were determined to be selectively localized on axons and axon terminals in the external median eminence and the hypothalamic arcuate nucleus by means of quantitative fine structural radioautography. This localization suggests that discrete populations of hypothalamic nerve terminals are potential targets for the direct effects of insulin and that insulin may act through synaptic mechanisms to influence hypothalamic circuits regulating energy balance and hypophyseal function.

Entities: Disease Species

Mesh：

Substances：
Insulin
Receptor, Insulin

Year: 1980 PMID： 6986652 DOI： 10.1126/science.6986652

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

36 in total

1. Involvement of the arcuate nucleus of the hypothalamus in interleukin-1-induced anorexia.

Authors: Teresa M Reyes; Paul E Sawchenko
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Review 2. Peripheral modulation of learning and memory: enkephalins as a model system.

Authors: G Schulteis; J L Martinez
Journal: Psychopharmacology (Berl) Date: 1992 Impact factor: 4.530

3. NH2-terminal specificity and axonal localization of adrenocorticotropin binding sites in rat median eminence.

Authors: M Van Houten; M N Khan; R J Walsh; G B Baquiran; L P Renaud; C Bourque; S Sgro; S Gauthier; M Chretien; B I Posner
Journal: Proc Natl Acad Sci U S A Date: 1985-02 Impact factor: 11.205

Review 4. Insulin transport into the brain.

Authors: Sarah M Gray; Eugene J Barrett
Journal: Am J Physiol Cell Physiol Date: 2018-05-30 Impact factor: 4.249

Review 5. Insulin and insulin-like growth factor receptors in the nervous system.

Authors: M Adamo; M K Raizada; D LeRoith
Journal: Mol Neurobiol Date: 1989 Spring-Summer Impact factor: 5.590

6. The hypophyseal pars tuberalis is enriched with distinct phosphotyrosine-containing proteins not detected in other areas of the brain and pituitary.

Authors: J W Unger; A M Moss; J N Livingston
Journal: Cell Tissue Res Date: 1993-06 Impact factor: 5.249

Insulin binding sites localized to nerve terminals in rat median eminence and arcuate nucleus.

1. Involvement of the arcuate nucleus of the hypothalamus in interleukin-1-induced anorexia.

Review 2. Peripheral modulation of learning and memory: enkephalins as a model system.

3. NH2-terminal specificity and axonal localization of adrenocorticotropin binding sites in rat median eminence.

Review 4. Insulin transport into the brain.

Review 5. Insulin and insulin-like growth factor receptors in the nervous system.

6. The hypophyseal pars tuberalis is enriched with distinct phosphotyrosine-containing proteins not detected in other areas of the brain and pituitary.

7. Cellular basis of direct insulin action in the central nervous system.

8. Transport of nutrients and hormones through the blood-brain barrier.

9. Increase by naloxone of arginine vasopressin and oxytocin responses to insulin-induced hypoglycemia in obese men.

10. Expression changes of hypothalamic Ahi1 in mice brain: implication in sensing insulin signaling.