Literature DB >> 698556

Indian childhood cirrhosis: an inherited disorder of tryptophan metabolism?

A M Sur, A Bhatti.   

Abstract

Urine samples from members of 29 families of patients with Indian childhood cirrhosis (ICC) and nine families with related disorders gave positive reactions when tested with ferric chloride. Column chromatography showed that this was due to the presence of abnormally large amounts of tryptophan metabolites, notably 3-hydroxyanthranilic acid. Affected pedigrees had a significantly greater prevalence of peptic ulcer, adult cirrhosis, diabetes mellitus, migraine, and Parkinsonism than a control population. ICC may result from an inborn error of tryptophan metabolism in susceptible ethnic groups.

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Year:  1978        PMID： 698556      PMCID： PMC1606987          DOI： 10.1136/bmj.2.6136.529

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  11 in total

1.  PEPTIC ULCER AND GASTRIC SECRETION IN PATIENTS WITH LIVER DISEASE.

Authors:  S TABAQCHALI; A M DAWSON
Journal:  Gut       Date:  1964-10       Impact factor: 23.059

2.  Autoimmune antibodies in infantile cirrhosis.

Authors:  P PRASAD
Journal:  Br Med J       Date:  1962-10-20

3.  Sources of upper alimentary tract hemorrhage in cirrhosis of the liver.

Authors:  D C FAINER; J A HALSTED
Journal:  J Am Med Assoc       Date:  1955-01-29

4.  The incidence of portal cirrhosis and fatty metamorphosis in patients dying with diabetes mellitus.

Authors:  W E JAQUES
Journal:  N Engl J Med       Date:  1953-09-10       Impact factor: 91.245

5.  The clinical significance of the co-existence of peptic ulcer and portal cirrhosis, with special reference to the problem of massive hemorrhage.

Authors:  W F LIPP; M H LIPSITZ
Journal:  Gastroenterology       Date:  1952-10       Impact factor: 22.682

6.  Morphological features of Indian childhood cirrhosis: the spectrum of changes and their significance.

Authors:  B K Aikat; T Bhattacharya; B N Walia
Journal:  Indian J Med Res       Date:  1974-07       Impact factor: 2.375

7.  Immunological picture in Indian childhood cirrhosis.

Authors:  R K Chandra
Journal:  Lancet       Date:  1970-03-14       Impact factor: 79.321

Review 8.  Testing the functional capacity of the tryptophan-niacin pathway in man by analysis of urinary metabolites.

Authors:  J M Price; R R Brown; N Yess
Journal:  Adv Metab Disord       Date:  1965

9.  Histopathological evolution of Indian childhood cirrhosis with emphasis on criteria of early diagnosis.

Authors:  B D Patel; S R Parekh; A R Chitale
Journal:  Indian Pediatr       Date:  1974-01       Impact factor: 1.411

10.  Plasma zinc concentration in Indian childhood cirrhosis.

Authors:  O P Ghai; K Vasuki
Journal:  Indian Pediatr       Date:  1971-07       Impact factor: 1.411
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  2 in total

1.  Indian childhood cirrhosis.

Authors: 
Journal:  Br Med J (Clin Res Ed)       Date:  1981-11-21

2.  Indian childhood cirrhosis in the United Kingdom.

Authors:  H J Klass; J K Kelly; T W Warnes
Journal:  Gut       Date:  1980-04       Impact factor: 23.059
  2 in total

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