Literature DB >> 698480

Adrenal origin of plasma catecholamines after decapitation: a study in normal and diabetic rats.

B A Berkowitz, R J Head.   

Abstract

The concentrations of catecholamines and the activities of dopamine-beta-hydroxylase were measured in blood obtained from decapitated diabetic and aged-matched control rats. The activity of dopamine-beta-hydroxylase in blood from diabetic rats was much greater (5 fold) than that seen for control rats. For both diabetic and control rats, decapitation was accompanied by an increase in levels of adrenaline and noradrenaline with no change in the activity of plasma dopamine-beta-hydroxylase. The results are consistent with a predominantly adrenal origin of catecholamines and extra-adrenal origin of dopamine-beta-hydroxylase. The high activity of dopamine-beta-hydroxylase in diabetes indicates either an increased activity of the sympathetic nervous system or changes in dopamine-beta-hydroxylase turnover.

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Year:  1978        PMID： 698480      PMCID： PMC1668258          DOI： 10.1111/j.1476-5381.1978.tb08632.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  9 in total

1.  Plasma catecholamine concentrations in unanesthetized rats during sleep, wakefulness, immobilization and after decapitation.

Authors:  C W Popper; C C Chiueh; I J Kopin
Journal:  J Pharmacol Exp Ther       Date:  1977-07       Impact factor: 4.030

2.  Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range.

Authors:  M Da Prada
Journal:  Life Sci       Date:  1976-10-15       Impact factor: 5.037

3.  A simple and sensitive assay for dopamine-beta-hydroxylase activity by dual-wavelength spectrophotometry.

Authors:  T Kato; H Kuzuya; T Nagatsu
Journal:  Biochem Med       Date:  1974-08

4.  Elevation of serum dopamine-beta-hydroxylase activity with forced immobilization.

Authors:  R M Weinshilboum; R Kvetnansky; J Axelrod; I J Kopin
Journal:  Nat New Biol       Date:  1971-04-28

5.  Photometric assay of dopamine- -hydroxylase activity in human blood.

Authors:  T Nagatsu; S Udenfriend
Journal:  Clin Chem       Date:  1972-09       Impact factor: 8.327

Review 6.  Isotope-derivative measurements of plasma norepinephrine and epinephrine in man.

Authors:  P E Cryer
Journal:  Diabetes       Date:  1976-11       Impact factor: 9.461

7.  Adrenal origin of the increase in plasma dopamine beta-hydroxylase and catecholamines induced by hemorrhagic hypotension in dogs.

Authors:  L Cubeddu; E Santiago; R Talmaciu; G Pinardi
Journal:  J Pharmacol Exp Ther       Date:  1977-12       Impact factor: 4.030

8.  Proportional release of norepinephrine and dopamine- -hydroxylase from sympathetic nerves.

Authors:  R M Weinshilboum; N B Thoa; D G Johnson; I J Kopin; J Axelrod
Journal:  Science       Date:  1971-12-24       Impact factor: 47.728

9.  The sympathetic nervous system in diabetic neuropathy. A clinical and pathological study.

Authors:  P A Low; J C Walsh; C Y Huang; J G McLeod
Journal:  Brain       Date:  1975-09       Impact factor: 13.501
  9 in total
  1 in total

1.  Conjoint radioenzymatic measurement of catecholamines, their catechol metabolites and DOPA in biological samples.

Authors:  H M Thiede; W Kehr
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-12       Impact factor: 3.000
  1 in total

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