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Literature DB >> 6983692

A T15-idiotype-positive T suppressor hybridoma does not use the T15 VH gene segment.

K Nakanishi, K Sugimura, Y Yaoita, K Maeda, S Kashiwamura, T Honjo, T Kishimoto.

Abstract

The T suppressive factor (TsF) released from a T15-idiotype-positive phosphocholine (PCho)-specific T hybridoma, F18-3-4, which was formed by fusion between BALB/c T cells and BW5147 thymoma, was immunochemically characterized. TsF inhibited the in vitro induction of both IgE and IgG1 antibody responses of 2,4-dinitrophenyl keyhole limpet hemocyanin (DNP-KLH)-primed spleen cells in the presence of PCho-KLH-DNP. TsF had the ability to bind to PCho determinants and possessed T15 idiotype determinants as well as Iad products. However, we were unable to detect either the rearrangement of the T15 VH gene or the presence of T15 VH gene transcripts in hybridomas by DNA and RNA blot hybridization analyses with the T15 VH DNA probe.

Entities: Chemical Disease Species

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Year: 1982 PMID： 6983692 PMCID： PMC347259 DOI： 10.1073/pnas.79.22.6984

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

21 in total

1. Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.

Authors: P S Thomas
Journal: Proc Natl Acad Sci U S A Date: 1980-09 Impact factor: 11.205

2. Coexistence of variable region of immunoglobulin heavy chain and I region gene products on antigen-specific suppressor T cells and suppressor T cell factor. A minimal model of functional antigen receptor of T cells.

Authors: T Tada; K Hayakawa; K Okumura; M Taniguchi
Journal: Mol Immunol Date: 1980-07 Impact factor: 4.407

3. Reconstitution of antigen-specific suppressor activity with translation products of mRNA.

Authors: M Taniguchi; T Tokuhisa; M Kanno; Y Yaoita; A Shimizu; T Honjo
Journal: Nature Date: 1982-07-08 Impact factor: 49.962

Review 4. Antigen receptors of T helper cells.

Authors: K Rajewsky; K Eichmann
Journal: Contemp Top Immunobiol Date: 1977

5. A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody.

Authors: S Crews; J Griffin; H Huang; K Calame; L Hood
Journal: Cell Date: 1981-07 Impact factor: 41.582

6. Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes.

Authors: Y Kurosawa; H von Boehmer; W Haas; H Sakano; A Trauneker; S Tonegawa
Journal: Nature Date: 1981-04-16 Impact factor: 49.962

7. Demonstration of T15 idiotype-positive effector and suppressor T cells for phosphorylcholine-specific delayed-type hypersensitivity response in CBA/N or (CBA/N X BALB/c)F1 male mice.

Authors: K Sugimura; T Kishimoto; K Maeda; Y Yamamura
Journal: Eur J Immunol Date: 1981-06 Impact factor: 5.532

8. Two distinct allotypic determinants on the antigen-specific suppressor and enhancing T cell factors that are encoded by genes linked to the immunoglobulin heavy chain locus.

Authors: T Tokuhisa; M Taniguchi
Journal: J Exp Med Date: 1982-01-01 Impact factor: 14.307

9. Helper and killer T cells do not express B cell immunoglobulin joining and constant region gene segments.

Authors: M Kronenberg; M M Davis; P W Early; L E Hood; J D Watson
Journal: J Exp Med Date: 1980-12-01 Impact factor: 14.307

10. The T suppressor cell alloantigen Tsud maps near immunoglobulin allotype genes and may be an heavy chain constant-region marker on a T cell receptor.

Authors: F L Owen; R Riblet; B A Taylor
Journal: J Exp Med Date: 1981-04-01 Impact factor: 14.307

9 in total

Review 1. Antigen-major histocompatibility complex-T cell receptors: inquiries into the immunological ménage à trois.

Authors: J Klein
Journal: Immunol Res Date: 1986 Impact factor: 2.829

2. Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets.

Authors: S M Hedrick; R N Germain; M J Bevan; M Dorf; I Engel; P Fink; N Gascoigne; E Heber-Katz; J Kapp; Y Kaufmann
Journal: Proc Natl Acad Sci U S A Date: 1985-01 Impact factor: 11.205

3. Anti-hypervariable region antibody induced by a defined peptide: an approach for studying the structural correlates of idiotypes.

Authors: P P Chen; R A Houghten; S Fong; G H Rhodes; T A Gilbertson; J H Vaughan; R A Lerner; D A Carson
Journal: Proc Natl Acad Sci U S A Date: 1984-03 Impact factor: 11.205

4. The D-JH complex is an intermediate to the complete immunoglobulin heavy-chain V-region gene.

Authors: Y Yaoita; N Matsunami; C Y Choi; H Sugiyama; T Kishimoto; T Honjo
Journal: Nucleic Acids Res Date: 1983-11-11 Impact factor: 16.971

5. Suppressor T-cell factor(s) display an altered pattern of Igh (immunoglobulin heavy chain locus) genetic restriction when developed in an Igh-congeneic host.

Authors: K T HayGlass; S J Naides; B Benacerraf; M S Sy
Journal: Proc Natl Acad Sci U S A Date: 1985-04 Impact factor: 11.205

6. Biased reading frames of pre-existing DH--JH coding joints and preferential nucleotide insertions at VH--DJH signal joints of excision products of immunoglobulin heavy chain gene rearrangements.

Authors: T Shimizu; H Yamagishi
Journal: EMBO J Date: 1992-12 Impact factor: 11.598