Literature DB >> 69831

Effect of triac on the developing heart.

E G Olsen, C Symons, C Hawkey.   

Abstract

Triac (diethanolamine salt of triiodothyroacetic acid) was administered by intramuscular injection to 12 pregnant female rats. These were divided into a control group and three other groups, each receiving different doses of triac. The effect of triac on the hearts of their offspring was studied morphologically. Histological examination showed evidence of only mild hypertrophy, but ultrastructurally, disarray of myocardial fibrils and other changes similar to those observed in patients with hypertrophic cardiomyopathy were found in the litter of the group receiving the highest dose. It is suggested that thyroid function should be studied in patients with obscure cardiac disease.

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Year:  1977        PMID： 69831     DOI： 10.1016/s0140-6736(77)92836-7

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  10 in total

1.  Pathology of hypertrophic cardiomyopathy.

Authors:  E G Olsen
Journal:  Postgrad Med J       Date:  1986-06       Impact factor: 2.401

2.  The effects of plasma from patients with Graves' disease on foetal mouse hearts in organ culture.

Authors:  A W Nathan; D B Longmore; C W Havard; P Dandona
Journal:  Br J Exp Pathol       Date:  1983-10

Review 3.  The frontiers of cardiomyopathy.

Authors:  J F Goodwin
Journal:  Br Heart J       Date:  1982-07

4.  Thyroid heart disease.

Authors:  C Symons
Journal:  Br Heart J       Date:  1979-03

5.  Response to thyrotrophin-releasing hormone in atrial dysrhythmias.

Authors:  C Symons; A Myers; D Kingstone; M Boss
Journal:  Postgrad Med J       Date:  1978-10       Impact factor: 2.401

6.  Asymmetric septal hypertrophy and hypothyroidism in children.

Authors:  D I Altman; J Murray; S Milner; R Dansky; S E Levin
Journal:  Br Heart J       Date:  1985-11

7.  Familial neurofibromatosis and hypertrophic cardiomyopathy.

Authors:  A P Fitzpatrick; R W Emanuel
Journal:  Br Heart J       Date:  1988-09

8.  Incidence of thyroid disease in cases of hypertrophic cardiomyopathy.

Authors:  R Bell; P V Barber; C L Bray; D C Beton
Journal:  Br Heart J       Date:  1978-11

9.  Cardiac abnormalities in children with hyperthyroidism.

Authors:  L A Lester; P C Sodt; B H Rich; A W Lucky; N Hutcheon; R A Arcilla
Journal:  Pediatr Cardiol       Date:  1982       Impact factor: 1.655

10.  Role of calcium in the induction of cardiac hypertrophy and myofibrillar disarray. Experimental studies of a possible cause of hypertrophic cardiomyopathy.

Authors:  P C Pearcé; C Hawkey; C Symons; E G Olsen
Journal:  Br Heart J       Date:  1985-10
  10 in total

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