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Literature DB >> 6982307

A monoclonal anti-DC1 antibody selectivity inhibits the generation of effector T cells mediating specific cytolytic activity.

G Corte, A Moretta, M E Cosulich, D Ramarli, A Bargellesi.

Abstract

The products of the DC locus have been shown to be structurally different from those of the DR locus. In this paper it is shown that, unlike anti-DR antibodies, a monoclonal antibody directed against DC1 does not affect proliferation of T cells in response to alloantigens or soluble antigens or production of Ig in a pokeweed mitogen-stimulated in vitro culture. However, the anti-DC1 inhibits the generation of effector T cells mediating specific cytolytic activity, whereas no inhibitory effect can be observed on natural killer and antibody-dependent cytotoxic cell activities.

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Year: 1982 PMID： 6982307 PMCID： PMC2186843 DOI： 10.1084/jem.156.5.1539

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

10 in total

1. Human Ia molecules carrying DC1 determinants differ in both alpha- and beta-subunits from Ia molecules carrying DR determinants.

Authors: G Corte; F Calabi; G Damiani; A Bargellesi; R Tosi; R Sorrentino
Journal: Nature Date: 1981-07-23 Impact factor: 49.962

2. Analysis of HLA-DR polymorphism by two-dimensional peptide mapping.

Authors: G Corte; G Damiani; F Calabi; M Fabbi; A Bargellesi
Journal: Proc Natl Acad Sci U S A Date: 1981-01 Impact factor: 11.205

3. Binding of one monoclonal antibody to human Ia molecules can be enhanced by a second monoclonal antibody.

Authors: R Tosi; N Tanigaki; R Sorrentino; R Accolla; G Corte
Journal: Eur J Immunol Date: 1981-09 Impact factor: 5.532

4. Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.

Authors: D A Shackelford; D L Mann; J J van Rood; G B Ferrara; J L Strominger
Journal: Proc Natl Acad Sci U S A Date: 1981-07 Impact factor: 11.205

5. Allogeneic mixed lymphocyte reactions in humans: pretreatment of either the stimulator or the responder cell population with monoclonal anti-Ia antibodies leads to an inhibition of cell proliferation.

Authors: R S Accolla; A Moretta; J C Cerottini
Journal: J Immunol Date: 1981-12 Impact factor: 5.422

6. Molecular identification of human Ia antigens coded for by a gene locus closely linked to HLA-DR locus.

Authors: N Tanigaki; R Tosi; D Pressman; G B Ferrara
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

7. Human T cell subpopulations defined by a monoclonal antibody. I. A small subset is responsible for proliferation to allogeneic cells or to soluble antigens and for helper activity for B cell differentiation.

Authors: G Corte; M C Mingari; A Moretta; G Damiani; L Moretta; A Bargellesi
Journal: J Immunol Date: 1982-01 Impact factor: 5.422

8. Human T cell subpopulations defined by a monoclonal antibody. II. Evidence for cell cooperation in the response to alloantigens and generation of cytolytic cells.

Authors: A Moretta; G Corte; M C Mingari; L Moretta
Journal: J Immunol Date: 1982-01 Impact factor: 5.422

9. Immunological dissection of human Ia molecules.

Authors: R Tosi; N Tanigaki; D Centis; G B Ferrara; D Pressman
Journal: J Exp Med Date: 1978-12-01 Impact factor: 14.307

10. Generation of cytotoxic T lymphocytes in vitro. I. Response of normal and immune mouse spleen cells in mixed leukocyte cultures.

Authors: J C Cerottini; H D Engers; H R Macdonald; T Brunner
Journal: J Exp Med Date: 1974-09-01 Impact factor: 14.307

10 in total

13 in total

Review 8. Autologous cellular immune response to primary and metastatic human melanomas and its regulation by DR antigens expressed on tumor cells.

Authors: G Parmiani; G Fossati; D Taramelli; A Anichini; A Balsari; C Gambacorti-Passerini; G Sciorelli; N Cascinelli
Journal: Cancer Metastasis Rev Date: 1985 Impact factor: 9.264

9. Antigen-specific HLA-restricted human T-cell lines. II. A GAT-specific T-cell line restricted by a determinant carried by an HLA-DQ molecule.

Authors: E J Ball; P Stastny
Journal: Immunogenetics Date: 1984 Impact factor: 2.846

10. Analysis of the structural heterogeneity and polymorphism of human Ia antigens. Four distinct subsets of molecules are coexpressed in the Ia pool of both DR1,1 homozygous and DR3,W6 heterozygous B cell lines.

Authors: R S Accolla
Journal: J Exp Med Date: 1984-02-01 Impact factor: 14.307

A monoclonal anti-DC1 antibody selectivity inhibits the generation of effector T cells mediating specific cytolytic activity.

1. Human Ia molecules carrying DC1 determinants differ in both alpha- and beta-subunits from Ia molecules carrying DR determinants.

2. Analysis of HLA-DR polymorphism by two-dimensional peptide mapping.

3. Binding of one monoclonal antibody to human Ia molecules can be enhanced by a second monoclonal antibody.

4. Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.

5. Allogeneic mixed lymphocyte reactions in humans: pretreatment of either the stimulator or the responder cell population with monoclonal anti-Ia antibodies leads to an inhibition of cell proliferation.

6. Molecular identification of human Ia antigens coded for by a gene locus closely linked to HLA-DR locus.

7. Human T cell subpopulations defined by a monoclonal antibody. I. A small subset is responsible for proliferation to allogeneic cells or to soluble antigens and for helper activity for B cell differentiation.

8. Human T cell subpopulations defined by a monoclonal antibody. II. Evidence for cell cooperation in the response to alloantigens and generation of cytolytic cells.

9. Immunological dissection of human Ia molecules.

10. Generation of cytotoxic T lymphocytes in vitro. I. Response of normal and immune mouse spleen cells in mixed leukocyte cultures.

1. Class II antigens on dendritic cells from the synovial fluids of patients with inflammatory arthritis.

2. HLA-DR, DP and DQ expression in the small intestine of patients with coeliac disease.

3. Molecular characterization of a subtype of DQw1 recognized by hapten-specific T cells.

4. Genetic and functional relationship of the HLA-DR and HLA-DQ antigens.

5. Ia-negative B-cell variants reveal a coordinate regulation in the transcription of the HLA class II gene family.

6. Differential tissue distribution and ontogeny of DC-1 and HLA-DR antigens.

7. Differential effects of gamma interferon on expression of HLA class II molecules controlled by the DR and DC loci.

Review 8. Autologous cellular immune response to primary and metastatic human melanomas and its regulation by DR antigens expressed on tumor cells.

9. Antigen-specific HLA-restricted human T-cell lines. II. A GAT-specific T-cell line restricted by a determinant carried by an HLA-DQ molecule.

10. Analysis of the structural heterogeneity and polymorphism of human Ia antigens. Four distinct subsets of molecules are coexpressed in the Ia pool of both DR1,1 homozygous and DR3,W6 heterozygous B cell lines.