Literature DB >> 6980684

Pharmacokinetics of metronidazole and its principal metabolites and their activity against Gardnerella vaginalis.

C S Easmon, C A Ison, C M Kaye, R M Timewell, S G Dawson.   

Abstract

The hydroxy metabolite of metronidazole was found to be more active against 21 strains of Gardnerella vaginalis than the parent compound and less affected by culture in carbon dioxide. After 400 mg oral metronidazole (Flagyl) plasma concentrations of the two agents were below the minimum inhibitory concentrations (MICs) for most G vaginalis strains tested. With 2 g metronidazole the plasma concentrations exceeded the MICs of the more sensitive strains. Even with the lower dose of metronidazole clinically useful concentration of metronidazole and its hydroxy metabolite were present in the urine. Urinary excretion of these compounds may contribute to the efficacy of metronidazole in the treatment of vaginitis associated with G vaginalis.

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Year:  1982        PMID： 6980684      PMCID： PMC1046059          DOI： 10.1136/sti.58.4.246

Source DB:  PubMed          Journal:  Br J Vener Dis        ISSN： 0007-134X


  11 in total

1.  Identification of the metabolites of metronidazole in the human vagina.

Authors:  R W Manthei; L G Feo; J E Stambaugh
Journal:  Wiad Parazytol       Date:  1969

2.  Sensitivity of Gardnerella vaginalis to metabolites of metronidazole and tinidazole.

Authors:  S Shanker; R Munro
Journal:  Lancet       Date:  1982-01-16       Impact factor: 79.321

3.  Nonspecific vaginitis: role of Haemophilus vaginalis and treatment with metronidazole.

Authors:  T A Pheifer; P S Forsyth; M A Durfee; H M Pollock; K K Holmes
Journal:  N Engl J Med       Date:  1978-06-29       Impact factor: 91.245

4.  Anaerobic bacteria in nonspecific vaginitis.

Authors:  C A Spiegel; R Amsel; D Eschenbach; F Schoenknecht; K K Holmes
Journal:  N Engl J Med       Date:  1980-09-11       Impact factor: 91.245

5.  Vaginitis revisited.

Authors:  S G Dawson; C A Ison; C S Easmon
Journal:  Br Med J (Clin Res Ed)       Date:  1981-11-14

6.  A rapid and specific semi-micro method involving high-pressure liquid chromatography for the assay of metronidazole in plasma, saliva, serum, urine and whole blood.

Authors:  C M Kaye; M G Sankey; L A Thomas
Journal:  Br J Clin Pharmacol       Date:  1980-05       Impact factor: 4.335

7.  Metronidazole metabolite and Gardnerella vaginalis (Corynebacterium vaginale)

Authors:  M J Baldson; D Jackson
Journal:  Lancet       Date:  1981-05-16       Impact factor: 79.321

8.  Excretion of lipoteichoic acid by group A streptococci. Influence of penicillin on excretion and loss of ability to adhere to human oral mucosal cells.

Authors:  M L Alkan; E H Beachey
Journal:  J Clin Invest       Date:  1978-03       Impact factor: 14.808

9.  Corynebacterium vaginale and vaginitis: a controlled trial of treatment.

Authors:  M J Balsdon; G E Taylor; L Pead; R Maskell
Journal:  Lancet       Date:  1980-03-08       Impact factor: 79.321

10.  Relative susceptibilities of Gardnerella vaginalis (Haemophilus vaginalis), Neisseria gonorrhoeae, and Bacteroides fragilis to Metronidazole and its two major metabolites.

Authors:  E D Ralph; Y E Amatnieks
Journal:  Sex Transm Dis       Date:  1980 Oct-Dec       Impact factor: 2.830
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  11 in total

1.  Rapid and Profound Shifts in the Vaginal Microbiota Following Antibiotic Treatment for Bacterial Vaginosis.

Authors:  Bryan T Mayer; Sujatha Srinivasan; Tina L Fiedler; Jeanne M Marrazzo; David N Fredricks; Joshua T Schiffer
Journal:  J Infect Dis       Date:  2015-02-12       Impact factor: 5.226

2.  Metronidazole in the treatment of non-specific vaginitis (NSV).

Authors:  F Jerve; T B Berdal; P Bohman; C C Smith; O K Evjen; H Gjønnaess; M Gaasemyr; L Hausken; K Hesla; E Hoftvedt
Journal:  Br J Vener Dis       Date:  1984-06

Review 3.  Metronidazole. A therapeutic review and update.

Authors:  C D Freeman; N E Klutman; K C Lamp
Journal:  Drugs       Date:  1997-11       Impact factor: 9.546

4.  Amine content of vaginal fluid from patients with trichomoniasis and gardnerella associated non-specific vaginitis.

Authors:  B E Sanderson; E White; M J Baldson
Journal:  Br J Vener Dis       Date:  1983-10

5.  Gardnerella vaginalis and anaerobic bacteria in genital disease.

Authors:  S Tabaqchali; M Wilks; R N Thin
Journal:  Br J Vener Dis       Date:  1983-04

6.  Antibiotic consideration in bacterial vaginosis.

Authors:  Jack D Sobel
Journal:  Curr Infect Dis Rep       Date:  2009-11       Impact factor: 3.725

Review 7.  Gardnerella vaginalis: characteristics, clinical considerations, and controversies.

Authors:  B W Catlin
Journal:  Clin Microbiol Rev       Date:  1992-07       Impact factor: 26.132

8.  Should male consorts of women with bacterial vaginosis be treated?

Authors:  H Moi; R Erkkola; F Jerve; G Nelleman; B Bymose; K Alaksen; E Tornqvist
Journal:  Genitourin Med       Date:  1989-08

9.  Metronidazole and hydroxymetronidazole central nervous system distribution: 1. microdialysis assessment of brain extracellular fluid concentrations in patients with acute brain injury.

Authors:  Denis Frasca; Claire Dahyot-Fizelier; Christophe Adier; Olivier Mimoz; Bertrand Debaene; William Couet; Sandrine Marchand
Journal:  Antimicrob Agents Chemother       Date:  2013-11-25       Impact factor: 5.191

10.  Liquid chromatography-tandem mass spectrometry for the simultaneous quantitation of ceftriaxone, metronidazole and hydroxymetronidazole in plasma from seriously ill, severely malnourished children.

Authors:  Martin Ongas; Joseph Standing; Bernhards Ogutu; Joseph Waichungo; James A Berkley; Karin Kipper
Journal:  Wellcome Open Res       Date:  2017-06-19
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