Literature DB >> 6980260

Demonstration of a third structurally distinct human Ia beta chain by two-dimensional gel electrophoresis.

R W Karr, C C Kannapell, J A Stein, T C Fuller, R J Duquesnoy, G E Rodey, D L Mann, H M Gebel, B D Schwartz.   

Abstract

Previous studies have indicated that HLA-DR homozygous cell lines express two Ia alpha and Ia beta chains that combine to form at least two Ia molecules. This report demonstrates by two-dimensional gel electrophoresis the existence of a third structurally distinct human Ia beta chain on DR2 and DR5 cell lines. This suggests that at least five separate genes control the expression of Ia molecules on HLA-DR homozygous cell lines.

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Year:  1982        PMID： 6980260      PMCID： PMC2186752          DOI： 10.1084/jem.156.2.652

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  8 in total

1.  High resolution two-dimensional electrophoresis of proteins.

Authors:  P H O'Farrell
Journal:  J Biol Chem       Date:  1975-05-25       Impact factor: 5.157

2.  Evidence for two homologous, but nonidentical, Ia molecules determined by the I-EC subregion.

Authors:  T L Delovitch; B H Barber
Journal:  J Exp Med       Date:  1979-07-01       Impact factor: 14.307

3.  Human Ia molecules carrying DC1 determinants differ in both alpha- and beta-subunits from Ia molecules carrying DR determinants.

Authors:  G Corte; F Calabi; G Damiani; A Bargellesi; R Tosi; R Sorrentino
Journal:  Nature       Date:  1981-07-23       Impact factor: 49.962

4.  Molecular relationships of the human B cell alloantigens, MT2, MB3, MT4, and DR5.

Authors:  R W Karr; C C Kannapell; J A Stein; H M Gebel; D L Mann; R J Duquesnoy; T C Fuller; G E Rodey; B D Schwartz
Journal:  J Immunol       Date:  1982-04       Impact factor: 5.422

5.  Isolation of I-A subregion-like molecules from subhuman primates and man.

Authors:  S M Goyert; J Silver
Journal:  Nature       Date:  1981-11-19       Impact factor: 49.962

6.  Detection of at least two distinct mouse I-E antigen molecules by the use of a monoclonal antibody.

Authors:  K Ozato; D H Sachs
Journal:  J Immunol       Date:  1982-02       Impact factor: 5.422

7.  Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.

Authors:  D A Shackelford; D L Mann; J J van Rood; G B Ferrara; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

8.  [Primary structure of class II human histocompatibility antigens. 1st communication. Amino acid sequence of the N-terminal 198 residues of the beta chain of a HLA-Dw2,2;DR2,2-alloantigen (author's transl)].

Authors:  H Kratzin; C Y Yang; H Götz; E Pauly; S Kölbel; G Egert; F P Thinnes; P Wernet; P Altevogt; N Hilschmann
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1981-12
  8 in total
  10 in total

1.  Correlation between an HLA-DQ alpha length polymorphism of messenger RNA and serologically defined specificities (DQw1, DRw53, DR3+5).

Authors:  P Loiseau; P Lehn; F Dautry; V Lepage; J Colombani; D Cohen; J Dausset; L Degos
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

2.  Primary structural sequence polymorphism in the human class II MHC antigen 33.1.

Authors:  M C Kuo; X M Li; G E Marti; J A Sachs; J A Sogn; J E Coligan; T J Kindt
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846

3.  Structural polymorphism of the DC1 light chains from DR1-, DR2-, and DRw6-positive cell lines.

Authors:  D A Shackelford; B Eibl; J L Strominger
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

4.  Histocompatibility antigens on human lymphoid cells.

Authors:  B D Schwartz
Journal:  Surv Immunol Res       Date:  1983

5.  Differential expression of Ia molecules by human monocytes.

Authors:  T A Gonwa; J D Stobo
Journal:  J Clin Invest       Date:  1984-09       Impact factor: 14.808

6.  The complexity of HLA-DS molecules. A homozygous cell line expresses multiple HLA-DS alpha chains.

Authors:  R W Karr; C Alber; S M Goyert; J Silver; R J Duquesnoy
Journal:  J Exp Med       Date:  1984-05-01       Impact factor: 14.307

7.  An HLA-DR5 homozygous cell line expresses two DS (I-A-like) molecules.

Authors:  R W Karr; C C Kannapell; R J Zangara; S M Goyert; J Silver; B D Schwartz
Journal:  J Exp Med       Date:  1983-10-01       Impact factor: 14.307

8.  A novel HLA-D/DR-like antigen specific for human B lymphoid cells. Biochemical evidence for similarity to but nonidentity with known HLA-D/DR antigens.

Authors:  G E Marti; M C Kuo; S Shaw; C C Chang; R Demars; J A Sogn; J E Coligan; T J Kindt
Journal:  J Exp Med       Date:  1983-12-01       Impact factor: 14.307

9.  Identification of the MT3 molecule using two-dimensional gel electrophoresis and alloantisera.

Authors:  M Suzuki; H Maeda; R Mukai; T Yabe; H Hamaguchi
Journal:  Immunogenetics       Date:  1983       Impact factor: 3.330

10.  Association of certain Ia allotypes with the occurrence of chronic lymphocytic leukemia. Recognition by a monoclonal anti-Ia reagent of a susceptibility determinant not in the DR series.

Authors:  A Nunez-Roldan; I Szer; T Toguchi; J Cuttner; R Winchester
Journal:  J Exp Med       Date:  1982-12-01       Impact factor: 14.307
  10 in total

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