Literature DB >> 6979312

Pharmacokinetics of potassium clavulanate in combination with amoxicillin in pediatric patients.

J D Nelson, H Kusmiesz, S Shelton.   

Abstract

Two dosages of a liquid suspension formulation of amoxicillin and potassium clavulanate were tested in 34 infants and children. The smaller dosage resulted in suboptimal plasma concentrations. With a greater dosage (3.3 mg of clavulanate per kg and 13.3 mg of amoxicillin per kg), the mean peak plasma concentrations were 1.6 micrograms clavulanic acid per ml and 4.9 micrograms amoxicillin per ml.

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Year:  1982        PMID： 6979312      PMCID： PMC181969          DOI： 10.1128/AAC.21.4.681

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  2 in total

1.  In vitro synergistic properties of clavulanic acid, with ampicillin, amoxycillin and ticarcillin.

Authors:  P A Hunter; K Coleman; J Fisher; D Taylor
Journal:  J Antimicrob Chemother       Date:  1980-07       Impact factor: 5.790

2.  Comparative pharmacokinetics of amoxicillin and ampicillin in infants and children.

Authors:  C M Ginsburg; G H McCracken; M L Thomas; J Clahsen
Journal:  Pediatrics       Date:  1979-11       Impact factor: 7.124
  2 in total
  11 in total

Review 1.  New formulations of amoxicillin/clavulanic acid: a pharmacokinetic and pharmacodynamic review.

Authors:  Amparo Sánchez Navarro
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 6.447

2.  Efficacy of high-dose amoxicillin-clavulanate against experimental respiratory tract infections caused by strains of Streptococcus pneumoniae.

Authors:  G Woodnutt; V Berry
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

3.  New sensitive bioassay for sulbactam in bovine tissues.

Authors:  G H Keeler; J P Stankewich; A E Girard; J J Rash
Journal:  Antimicrob Agents Chemother       Date:  1988-09       Impact factor: 5.191

4.  Pharmacokinetic study of a paediatric formulation of amoxycillin and clavulanic acid in children.

Authors:  C H van Niekerk; J van den Ende; H K Hundt; E A Louw
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

5.  Single-dose pharmacokinetics of intravenous clavulanic acid with amoxicillin in pediatric patients.

Authors:  U B Schaad; P A Casey; D L Cooper
Journal:  Antimicrob Agents Chemother       Date:  1983-02       Impact factor: 5.191

Review 6.  Clinical pharmacokinetics of enzyme inhibitors in antimicrobial chemotherapy.

Authors:  I D Watson; M J Stewart; D J Platt
Journal:  Clin Pharmacokinet       Date:  1988-09       Impact factor: 6.447

Review 7.  Amoxicillin/clavulanic acid. An update of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Authors:  P A Todd; P Benfield
Journal:  Drugs       Date:  1990-02       Impact factor: 9.546

8.  Amoxicillin combined with clavulanic acid for the treatment of soft tissue infections in children.

Authors:  G R Fleisher; C M Wilmott; J M Campos
Journal:  Antimicrob Agents Chemother       Date:  1983-11       Impact factor: 5.191

9.  Differential effect of impaired renal function on the kinetics of clavulanic acid and amoxicillin.

Authors:  F F Horber; F J Frey; C Descoeudres; A T Murray; F C Reubi
Journal:  Antimicrob Agents Chemother       Date:  1986-04       Impact factor: 5.191

10.  Simultaneous Determination of Potassium Clavulanate and Amoxicillin Trihydrate in Bulk, Pharmaceutical Formulations and in Human Urine Samples by UV Spectrophotometry.

Authors:  Rajinder Singh Gujral; Sk Manirul Haque
Journal:  Int J Biomed Sci       Date:  2010-12
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