Literature DB >> 697754

Effect of oestrogen and 1,25-dihydroxycholecalciferol on 25-hydroxycholecalciferol metabolism in primary chick kidney-cell cultures.

E Spanos, D I Barrett, K T Chong, I MacIntyre.   

Abstract

Primary cultures of chick kidney cells convert 25-hydroxycholecalciferol into more-polar metabolites. Cells from vitamin D-deficient chicks have high 25-hydroxycholecalciferol 1 alpha-hydroxylase (1 alpha-hydroxylase) activity, but no 25-hydroxycholecalciferol 24-hydroxylase (24-hydroxylase) activity. Physiological concentrations of 1,25-dihydroxycholeclaciferol suppress 1 alpha-hydroxylase and induce 24-hydroxylase activity. The inhibition of 1 alpha-hydroxylase preceded the induction of 24-hydroxylase. In contrast, oestradiol-17 beta had no effect on the activity of either hydroxylase under a variety of experimental conditions. These results clearly demonstrate that 1,25-dihydroxycholecalciferol, but not oestrogen, acts directly on the kidney cells to regulate the metabolism of 25-hydroxycholecalciferol.

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Year:  1978        PMID： 697754      PMCID： PMC1185903          DOI： 10.1042/bj1740231

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  Mechanisms of the renal response to plasma volume expansion.

Authors:  E L ATKINS; J W PEARCE
Journal:  Can J Biochem Physiol       Date:  1959-01

2.  Circulating 1alpha,25-dihydroxyvitamin D in the chicken: enhancement by injection of prolactin and during egg laying.

Authors:  E Spanos; J W Pike; M R Haussler; K W Colston; I M Evans; A M Goldner; T A McCain; I MacIntyre
Journal:  Life Sci       Date:  1976-12-01       Impact factor: 5.037

3.  Modulation of kidney 25-hydroxyvitamin D3 metabolism by 1alpha,25-dihydroxyvitamin D3 in thyroparathyroidectomized rats.

Authors:  T J Omdahl
Journal:  Life Sci       Date:  1976-12-15       Impact factor: 5.037

4.  Regulation of vitamin D: an evolutionary view.

Authors:  I MacIntyre; K W Colston; I M Evans; E Lopez; S J MacAuley; J Piegnoux-Deville; E Spanos; M Szelke
Journal:  Clin Endocrinol (Oxf)       Date:  1976       Impact factor: 3.478

5.  Control of 25-hydroxycholecalciferol metabolism by parathyroid glands.

Authors:  M Garabedian; M F Holick; H F Deluca; I T Boyle
Journal:  Proc Natl Acad Sci U S A       Date:  1972-07       Impact factor: 11.205

6.  Regulation of 25-hydroxyvitamin D3-1-hydroxylase in vivo.

Authors:  H L Henry; R J Midgett; A W Norman
Journal:  J Biol Chem       Date:  1974-12-10       Impact factor: 5.157

7.  Feedback control of vitamin D metabolism by a nuclear action of 1,25-dihydroxycholecalciferol on the kidney.

Authors:  R G Larkins; S J MacAuley; I MacIntyre
Journal:  Nature       Date:  1974-11-29       Impact factor: 49.962

8.  Metabolism of 25-hydroxy-vitamin D3 by primary cultures of chick kidney cells.

Authors:  H L Henry
Journal:  Biochem Biophys Res Commun       Date:  1977-01-24       Impact factor: 3.575

9.  25-Hydroxyvitamin D3-24-hydroxylase. Subcellular location and properties.

Authors:  J C Knutson; H F DeLuca
Journal:  Biochemistry       Date:  1974-03-26       Impact factor: 3.162

10.  Feedback regulation of vitamin D metabolism by 1,25-dihydroxycholecalciferol.

Authors:  K W Colston; I M Evans; T C Spelsberg; I MacIntyre
Journal:  Biochem J       Date:  1977-04-15       Impact factor: 3.857
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  9 in total

1.  1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation.

Authors:  D D Bikle; M K Nemanic; E Gee; P Elias
Journal:  J Clin Invest       Date:  1986-08       Impact factor: 14.808

2.  The renal metabolism of 25-hydroxyvitamin D3 in the rat: regulation by 1,25-dihydroxyvitamin D3.

Authors:  R T Turner; N H Bell; D J Baylink
Journal:  Calcif Tissue Int       Date:  1983-07       Impact factor: 4.333

3.  Regulation of vitamin D metabolism by calcium and phosphate ions in isolated renal tubules.

Authors:  E Spanos; H Freake; S J MacAuley; I MacIntyre
Journal:  Biochem J       Date:  1981-04-15       Impact factor: 3.857

4.  Salmon calcitonin-induced stimulation of 1 alpha,25-dihydroxycholecalciferol synthesis in rats involving a mechanism independent of adenosine 3':5'-cyclic monophosphate.

Authors:  N Horiuchi; H Takahashi; T Matsumoto; N Takahashi; E Shimazawa; T Suda; E Ogata
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857

5.  Regulation of the metabolism of 25-hydroxyvitamin D3 in primary cultures of chick kidney cells.

Authors:  U Trechsel; J P Bonjour; H Fleisch
Journal:  J Clin Invest       Date:  1979-07       Impact factor: 14.808

6.  Local action of phosphate depletion and insulin-like growth factor 1 on in vitro production of 1,25-dihydroxyvitamin D by cultured mammalian kidney cells.

Authors:  L Condamine; C Menaa; F Vrtovsnik; F Vztovsnik; G Friedlander; M Garabédian
Journal:  J Clin Invest       Date:  1994-10       Impact factor: 14.808

7.  Vitamin D-dependent rickets type II. Defective induction of 25-hydroxyvitamin D3-24-hydroxylase by 1,25-dihydroxyvitamin D3 in cultured skin fibroblasts.

Authors:  G T Gamblin; U A Liberman; C Eil; R W Downs; D A DeGrange; S J Marx
Journal:  J Clin Invest       Date:  1985-03       Impact factor: 14.808

8.  Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate.

Authors:  B P Halloran; D D Bikle; M J Levens; M E Castro; R K Globus; E Holton
Journal:  J Clin Invest       Date:  1986-09       Impact factor: 14.808

9.  Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3. Significance of the free 1,25-dihydroxyvitamin D3 concentration.

Authors:  R Bouillon; F A Van Assche; H Van Baelen; W Heyns; P De Moor
Journal:  J Clin Invest       Date:  1981-03       Impact factor: 14.808
  9 in total

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