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Literature DB >> 6976417

Tthyd, a new thymocyte alloantigen linked to Igh-1. Implications for a switch mechanism for T cell antigen receptors.

Abstract

Tthyd is an alloantigen coded for by a gene(s) near the immunoglobulin locus on chromosome 12 in the mouse. This T cell-specific antigen may be the third member of a family of antigen receptors on T cells encoded by a cluster of genes in the IgT-C region. This antigen is preferentially expressed on thymocytes in contrast to Tindd or Tsud that are expressed on peripheral T cells. The hypothesis that T cell receptors undergo a switch in surface isotype upon maturation is discussed.

Entities: Chemical Gene Species

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Year: 1982 PMID： 6976417 PMCID： PMC2186581 DOI： 10.1084/jem.155.1.52

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

27 in total

1. Induction of T and B cell immunity by anti-idiotypic antibody.

Authors: K Eichmann; K Rajewsky
Journal: Eur J Immunol Date: 1975-10 Impact factor: 5.532

2. Continuous cultures of fused cells secreting antibody of predefined specificity.

Authors: G Köhler; C Milstein
Journal: Nature Date: 1975-08-07 Impact factor: 49.962

3. In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells.

Authors: M J Bevan
Journal: Nature Date: 1977-09-29 Impact factor: 49.962

4. Idiotype-specific T helper cells are required to induce idiotype-positive B memory cells to secrete antibody.

Authors: R Woodland; H Cantor
Journal: Eur J Immunol Date: 1978-08 Impact factor: 5.532

Review 5. Studies of structure and immunosuppression of cross-reactive idiotype in strain A mice.

Authors: A Nisonoff; S T Ju; F L Owen
Journal: Immunol Rev Date: 1977 Impact factor: 12.988

6. Isolated hapten-binding receptors of sensitized lymphocytes. I. Receptors from nylon wool-enriched mouse T lymphocytes lack serological markers of immunoglobulin constant domains but express heavy chain variable portions.

Authors: U Krawinkel; M Cramer; T Imanishi-Kari; R S Jack; K Rajewsky; O Mäkelä
Journal: Eur J Immunol Date: 1977-08 Impact factor: 5.532

7. Towards a network theory of the immune system.

Authors: N K Jerne
Journal: Ann Immunol (Paris) Date: 1974-01

8. Organization of immunoglobulin heavy chain genes and allelic deletion model.

Authors: T Honjo; T Kataoka
Journal: Proc Natl Acad Sci U S A Date: 1978-05 Impact factor: 11.205

9. Binding to idiotypic determinants of large proportions of thymus-derived lymphocytes in idiotypically suppressed mice.

Authors: F L Owen; S T Ju; A Nisonoff
Journal: Proc Natl Acad Sci U S A Date: 1977-05 Impact factor: 11.205

10. H-2 restriction of virus-specific cytotoxicity across the H-2 barrier. Separate effector T-cell specificities are associated with self-H-2 and with the tolerated allogeneic H-2 in chimeras.

Authors: R M Zinkernagel
Journal: J Exp Med Date: 1976-10-01 Impact factor: 14.307

13 in total

Review 1. Mouse chromosome 12.

Authors: P D'Eustachio
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

2. Structural analysis of antigen-specific Ia-bearing regulatory T-cell factors: gel electrophoretic analysis of the antigen-specific augmenting T -cell factor.

Authors: S Miyatani; K Hiramatsu; P B Nakajima; F L Owen; T Tada
Journal: Proc Natl Acad Sci U S A Date: 1983-10 Impact factor: 11.205

3. DNA sequence associated with chromosome translocations in mouse plasmacytomas.

Authors: L J Harris; P D'Eustachio; F H Ruddle; K B Marcu
Journal: Proc Natl Acad Sci U S A Date: 1982-11 Impact factor: 11.205

4. Chromosomal mapping of the mink cell focus-inducing and xenotropic env gene family in the mouse.

Authors: C Blatt; K Mileham; M Haas; M N Nesbitt; M E Harper; M I Simon
Journal: Proc Natl Acad Sci U S A Date: 1983-10 Impact factor: 11.205

5. Antigenic polypeptide fragments of a receptor related to the Fab fragment of human immunoglobulin from thymus-derived lymphocytes.

Authors: J J Marchalonis; J C Hunt; J Maxwell; A C Wang
Journal: Proc Natl Acad Sci U S A Date: 1982-08 Impact factor: 11.205

6. Monoclonal alloantibodies specific for the constant region of T cell antigen receptors.

Authors: T Tokuhisa; Y Komatsu; Y Uchida; M Taniguchi
Journal: J Exp Med Date: 1982-09-01 Impact factor: 14.307

7. Tpre, a new alloantigen encoded in the IgT-C region of chromosome 12, is expressed on bone marrow of nude mice, fetal T cell hybrids, and fetal thymus.

Authors: F L Owen
Journal: J Exp Med Date: 1983-02-01 Impact factor: 14.307

8. Genes for the mouse T cell alloantigens Tpre, Tthy, Tind, and Tsu are closely linked near Igh on chromosome 12.

Authors: F L Owen; R Riblet
Journal: J Exp Med Date: 1984-01-01 Impact factor: 14.307

9. Products of the IgT-C region of chromosome 12 are maturational markers for T cells. Sequence of appearance in immunocompetent T cells parallels ontogenetic appearance of Tthyd, Tindd, and Tsud.

Authors: F L Owen
Journal: J Exp Med Date: 1982-09-01 Impact factor: 14.307

10. Modulation of Tthy alloantigen expression in the neonatal mouse. The Tthy-bearing thymocyte is a precursor for the peripheral cells expressing Tind and Tsu.

Authors: S K Keesee; F L Owen
Journal: J Exp Med Date: 1983-01-01 Impact factor: 14.307