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Literature DB >> 6976318

H-2-Restricted lethal graft-versus-host diseases.

Abstract

T cells from radiation chimeras in several strain combinations cause lethal GVHD in irradiated, bone-marrow-protected mice which share the D end of the H-2 complex with the T cells and also have foreign determinants. This phenomenon was not found with T cells from normal mice. I suggest that H-2-restricted GVD cells may be present in normal mice, but their effects may be masked by unrestricted GVH cells, which however, develop more slowly in the chimeras so that lethality due to restricted cells can be observed.

Entities: Disease Species

Mesh：

Substances：
H-2 Antigens

Year: 1981 PMID： 6976318 DOI： 10.1007/BF00350124

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

9 in total

1. Role of major histocompatibility complex gene products in delayed-type hypersensitivity.

Authors: J F Miller; M A Vadas; A Whitelaw; J Gamble
Journal: Proc Natl Acad Sci U S A Date: 1976-07 Impact factor: 11.205

2. A rapid method for the isolation of functional thymus-derived murine lymphocytes.

Authors: M H Julius; E Simpson; L A Herzenberg
Journal: Eur J Immunol Date: 1973-10 Impact factor: 5.532

3. H-2 dependence of co-operation between T and B cells in vivo.

Authors: B Kindred; D C Shreffler
Journal: J Immunol Date: 1972-11 Impact factor: 5.422

4. The role of macrophages in the generation of T-helper cells. I. The requirement for macrophages in helper cell induction and characteristics of the macrophage-T cell interaction.

Authors: P Erb; M Feldmann
Journal: Cell Immunol Date: 1975-10 Impact factor: 4.868

5. In vivo responses of alloreactive lymphocytes stimulated in vitro. Helper-cell activity of MLR-primed lymphocytes.

Authors: R B Corley; B Kindred
Journal: Scand J Immunol Date: 1977 Impact factor: 3.487

6. Capacity of genetically different T lymphocytes to induce lethal graft-versus-host disease correlates with their capacity to generate suppression but not with their capacity to generate anti-F1 killer cells. A non-H-2 locus determines the inability to induce lethal graft-versus-host disease.

Authors: E H Van Elven; A G Rolink; F V Veen; E Gleichmann
Journal: J Exp Med Date: 1981-06-01 Impact factor: 14.307

7. H-2 compatability requirement for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. Different cytotoxic T-cell specificities are associated with structures coded for in H-2K or H-2D;.

Authors: R M Zinkernagel; P C Doherty
Journal: J Exp Med Date: 1975-06-01 Impact factor: 14.307

8. Cell-mediated lympholysis of trinitrophenyl-modified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by H-2K and H-2D serological regions of the murine major histocompatibility complex.

Authors: G M Shearer; T G Rehn; C A Garbarino
Journal: J Exp Med Date: 1975-06-01 Impact factor: 14.307

9. Cell interactions between histoincompatible T and B lymphocytes. II. Failure of physiologic cooperative interactions between T and B lymphocytes from allogeneic donor strains in humoral response to hapten-protein conjugates.

Authors: D H Katz; T Hamaoka; B Benacerraf
Journal: J Exp Med Date: 1973-06-01 Impact factor: 14.307

9 in total

4 in total