Literature DB >> 6975824

Systemic lupus erythematosus in a patient with C4 deficiency.

M B Urowitz, D D Gladman, J O Minta.   

Abstract

A 40-year-old female with systemic lupus erythematosus was found to be totally deficient in the 4th component of complement and to be lacking in Chido and Rodgers blood group substances on red cells and in plasma. Family studies were suggestive of a linkage of the C4 deficiency with an HLA haplotype. C2 in the patient's serum was 50% of normal but other complement components and alternative pathway functions were normal. Chemotactic and opsonic activities in the patient's serum were diminished.

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Year:  1981        PMID: 6975824

Source DB:  PubMed          Journal:  J Rheumatol        ISSN: 0315-162X            Impact factor:   4.666


  5 in total

Review 1.  Lupus diseases associated with hereditary and acquired deficiencies of complement.

Authors:  V Agnello
Journal:  Springer Semin Immunopathol       Date:  1986

2.  Selective C4 deficiency, systemic lupus erythematosus, and Whipple's disease.

Authors:  M Ehrenfeld; M B Urowitz; M E Platts
Journal:  Ann Rheum Dis       Date:  1984-02       Impact factor: 19.103

3.  Association of Sjögren's syndrome with C4 deficiency, defective reticuloendothelial function and circulating immune complexes.

Authors:  P Hersey; S Lawrence; D Prendergast; C Bindon; W Benson; P Valk
Journal:  Clin Exp Immunol       Date:  1983-06       Impact factor: 4.330

4.  Inherited incomplete deficiency of the fourth component of complement (C4) determined by a gene not linked to human histocompatibility leukocyte antigens.

Authors:  W A Muir; S Hedrick; C A Alper; O D Ratnoff; B Schacter; J J Wisnieski
Journal:  J Clin Invest       Date:  1984-10       Impact factor: 14.808

5.  Genetic deficiency of C4, C2 or C1q and lupus syndromes. Association with anti-Ro (SS-A) antibodies.

Authors:  O Meyer; G Hauptmann; G Tappeiner; H D Ochs; F Mascart-Lemone
Journal:  Clin Exp Immunol       Date:  1985-12       Impact factor: 4.330

  5 in total

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