Literature DB >> 6975739

Increased serum salicylate metabolites with age in patients receiving chronic acetylsalicylic acid therapy.

P R Montgomery, D S Sitar.   

Abstract

A high pressure liquid chromatographic method was used to measure the serum concentrations of salicylic, salicyluric and gentisic acids in patients receiving chronic acetylsalicylic acid therapy. There was good correlation between this method and the established colorimetric assay for salicylic acid. The concentration of gentisic and salicyluric acids were increased in patients older than 60 years. No correlation was found with sex, concomitant ingestion of other drugs, serum creatinine or serum albumin.

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Year:  1981        PMID： 6975739     DOI： 10.1159/000212493

Source DB:  PubMed          Journal:  Gerontology        ISSN： 0304-324X            Impact factor:   5.140


  9 in total

1.  Aromatic hydroxylation as a potential measure of hydroxyl-radical formation in vivo. Identification of hydroxylated derivatives of salicylate in human body fluids.

Authors:  M Grootveld; B Halliwell
Journal:  Biochem J       Date:  1986-07-15       Impact factor: 3.857

Review 2.  The pharmacokinetics of non-steroidal anti-inflammatory drugs in the elderly.

Authors:  K W Woodhouse; H Wynne
Journal:  Clin Pharmacokinet       Date:  1987-02       Impact factor: 6.447

Review 3.  Aspirin and the elderly. Current status.

Authors:  C Silagy
Journal:  Drugs Aging       Date:  1993 Jul-Aug       Impact factor: 3.923

4.  Influence of age, sex, pregnancy and protein-calorie malnutrition on the pharmacokinetics of salicylate in rats.

Authors:  D R Varma; T L Yue
Journal:  Br J Pharmacol       Date:  1984-05       Impact factor: 8.739

5.  Quantitation of the hydroxyl radical adducts of salicylic acid by micellar electrokinetic capillary chromatography: oxidizing species formed by a Fenton reaction.

Authors:  M Tomita; T Okuyama; S Watanabe; H Watanabe
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

6.  Interaction of isoxicam with acetylsalicylic acid.

Authors:  M Esquivel; F Cussenot; R I Ogilvie; D S East; D H Shaw
Journal:  Br J Clin Pharmacol       Date:  1984-10       Impact factor: 4.335

7.  The effects of age and sex on the disposition of acetylsalicylic acid and its metabolites.

Authors:  P C Ho; E J Triggs; D W Bourne; V J Heazlewood
Journal:  Br J Clin Pharmacol       Date:  1985-05       Impact factor: 4.335

8.  Pharmacokinetics of aspirin in aged Indians.

Authors:  D C Dhasmana; D Chandra; G G Mansharamani
Journal:  Eur J Clin Pharmacol       Date:  1990       Impact factor: 2.953

Review 9.  Clinical pharmacokinetics of non-steroidal anti-inflammatory drugs.

Authors:  R K Verbeeck; J L Blackburn; G R Loewen
Journal:  Clin Pharmacokinet       Date:  1983 Jul-Aug       Impact factor: 6.447
  9 in total

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