| Literature DB >> 6975672 |
L H Phuc, M Papiernik, S Berrih, D Duval.
Abstract
Pregnancy-induced thymic atrophy was studied in mice during the course of syngeneic gestation and the post-partum period. Cortical thymocytes were greatly reduced in number as shown by the binding of fluorescein-labelled PNA. The pool of steroid-resistant (SR) medullary thymocytes appeared unchanged in pregnant mice when studied by means of a specific heteroantiserum (SRCA). Therefore, in pregnant mice, these two surface markers demonstrated that thymic atrophy was linked to steroid-sensitive (SS) cortical cell reduction. The presumed hydrocortisone resistance of the mother's remaining thymocytes is not related to a difference in the number of steroid receptors as determined by 3H-dexamethasone binding.Entities:
Mesh:
Substances:
Year: 1981 PMID: 6975672 PMCID: PMC1537357
Source DB: PubMed Journal: Clin Exp Immunol ISSN: 0009-9104 Impact factor: 4.330