Literature DB >> 6974093

Acetylation of procainamide and isoniazid by a rat liver-N-acetyl-transferase.

E Kattner, R Dubbels, W Schloot.   

Abstract

The genetic variation of the enzyme isoniazid-N-acetyltransferase has been studied in man and other species. Homogenates of liver samples of adult LEW rats also acetylate procainamide. The kinetic properties of isoniazid and procainamide acetylation are similar and are consistent with a ping-pong Bi-Bi mechanism. The experimental data support the hypothesis that one acetyltransferase catalyses both procainamide and isoniazid. Furthermore, a simple spectrophotometric assay to determine procainamide acetylation is presented.

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Year:  1981        PMID： 6974093     DOI： 10.1007/BF03189472

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  5 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

Review 2.  [Psychopharmacogentics].

Authors:  W Schloot; H W Goedde
Journal:  Med Klin       Date:  1976-03-19

3.  Acetylation of procaine amide in man. A preliminary communication.

Authors:  E Karlsson; G Aberg; P Collste; L Molin; B Norlander; F Sjöqvist
Journal:  Eur J Clin Pharmacol       Date:  1975       Impact factor: 2.953

4.  Comparison of the acetylation of procainamide and sulfadimidine in man.

Authors:  K Frislid; M Berg; V Hansteen; P K Lunde
Journal:  Eur J Clin Pharmacol       Date:  1976-03-22       Impact factor: 2.953

5.  Sulfadimidine and isoniazid loading in man and laboratory rats. Pharmacokinetic and pharmacogenetic results on drug acetylation.

Authors:  R Dubbels; E Kattner; D Sell-Maurer; W Schloot
Journal:  Arzneimittelforschung       Date:  1980
  5 in total

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