| Literature DB >> 6973756 |
R T Dorr, J R Powell, M Heick, D W Barry.
Abstract
A 24-year-old female with Hodgkin's disease and Pneumocystis carinii pneumonia was tested with trimethoprim/sulphamethoxazole (TMP/SMX) tablets. Because treatment failure was feared owing to chronic emesis potentially resulting in incomplete drug absorption, the same TMP/SMX dose was administered by rectal suppositories after the 5th day of oral dosing. The relative fractions (rectal/oral) or the suppository dose absorbed for TMP and SMX were 3.0% and 19.5% respectively. When TMP/SMX treatment is required and the oral route is not practical, the investigational i.v. preparation should be obtained.Entities:
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Year: 1981 PMID： 6973756 PMCID： PMC2424805 DOI： 10.1136/pgmj.57.664.123
Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401