Literature DB >> 6973701

The filum terminale of the frog spinal cord, a nontransformed glial preparation: II. Uptake of serotonin.

T Ritchie, S Glusman, B Haber.   

Abstract

The uptake of 5-HT was measured in the frog filum terminale (FT), a preparation composed almost exclusively of normal glia. [3H]5-HT was taken up by the FT via a high-affinity, sodium-dependent, temperature-sensitive transport system having a Km of 0.7 microM. In addition, a variety of drugs and aromatic amines known to selectively inhibit 5-HT uptake by synaptosomes and brain slices affected the uptake of 5-HT by the FT in qualitatively similar manner. The FT was shown to accumulate [3H]5-HT at rates significantly greater than the lumbar enlargement which contains both neurons and glia. The glial accumulation of 5-HT by the FT was verified by autoradiography. These findings strongly support the suggestion that glia may modulate aminergic transmission by competing with neurons for the reuptake of neuronally released amines.

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Year:  1981        PMID： 6973701     DOI： 10.1007/BF00963859

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  24 in total

1.  Estimation of parameters in double uptake systems.

Authors:  H T Hutchison; B Haber
Journal:  Anal Biochem       Date:  1975-10       Impact factor: 3.365

2.  On the regional and specific serotonin uptake inhibition by LM 5008.

Authors:  G Le Fur; M Kabouche; A Uzan
Journal:  Life Sci       Date:  1978-11-09       Impact factor: 5.037

3.  A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine.

Authors:  D T Wong; J S Horng; F P Bymaster; K L Hauser; B B Molloy
Journal:  Life Sci       Date:  1974-08-01       Impact factor: 5.037

4.  Characterization of taurine uptake by neuronal and glial cells in culture.

Authors:  J Borg; V J Balcar; J Mark; P Mandel
Journal:  J Neurochem       Date:  1979-06       Impact factor: 5.372

5.  Effects of 5,6-dihydroxytryptamine on monoaminergic neurones in the central nervous system of the rat.

Authors:  H G Baumgarten; K D Evetts; R B Holman; L L Iversen; M Vogt; G Wilson
Journal:  J Neurochem       Date:  1972-06       Impact factor: 5.372

6.  Kinetics of serotonin accumulation into synaptosomes of rat brain--effects of amphetamine and chloroamphetamines.

Authors:  D T Wong; J S Horng; R W Fuller
Journal:  Biochem Pharmacol       Date:  1973-02-01       Impact factor: 5.858

7.  An in vitro model for the study of psychotropic drugs and as a criterion of antidepressant activity.

Authors:  M H Kannengiesser; P Hunt; J P Raynaud
Journal:  Biochem Pharmacol       Date:  1973-01-01       Impact factor: 5.858

8.  Uptake of biogenic amines by glial cells in culture I. A neuronal-like transport system for serotonin.

Authors:  R L Suddith; H T Hutchison; B Haber
Journal:  Life Sci       Date:  1978-06-26       Impact factor: 5.037

9.  The filum terminale of the frog spinal cord, a non transformed preparation: I. Morphology and uptake of gamma-aminobutyric acid.

Authors:  S Glusman; M Pacheco; A González Robles; B Haber
Journal:  Brain Res       Date:  1979-08-24       Impact factor: 3.252

10.  Evidence for net uptake of GABA into mouse astrocytes in primary cultures--its sodium dependence and potassium independence.

Authors:  L Hertz; P H Wu; A Schousboe
Journal:  Neurochem Res       Date:  1978-06       Impact factor: 3.996
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  2 in total

1.  Expression of preproenkephalin mRNA by cultured astrocytes and neurons.

Authors:  M H Vilijn; P J Vaysse; R S Zukin; J A Kessler
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

2.  Biphasic Effect of Buspirone on the H-Reflex in Acute Spinal Decerebrated Mice.

Authors:  Yann Develle; Hugues Leblond
Journal:  Front Cell Neurosci       Date:  2020-01-15       Impact factor: 5.505
  2 in total

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