Literature DB >> 6973139

[Haemorrhagic necrosis of the digestive tract consecutive to massive digitalis intoxication (author's transl)].

O Patart, M Desnos, G Leroy, Y Lauru, M Mogenet, M Garbay, A Barrillon, A Gerbaux.   

Abstract

A 60-year-old man under digitalis treatment for hypertensive heart tried to commit suicide by absorbing a 15 mg dose of digitoxin. Severe intestinal bleeding occurred 12 hours later, followed by pseudo-occlusive syndrome and ischaemia of the distal lower limbs. On abdominal incision the whole gut was found to be invaded by haemorrhagic necrosis and perforated on three points. The patients subsequently died of peritonitis. The responsibility of digitoxin in these events was demonstrated by the absence of any other cause of ischaemia, such as heart failure, shock, arrhythmia, consumption coagulopathy or use of sympathomimetic drugs. This case shows that the vasoconstrictor effect of digitalis, experimentally demonstrated but clinically controversial, is a reality, and that digitalis compounds are contra-indicated in patients with haemorrhagic necrosis of the digestive tract.

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Year:  1981        PMID: 6973139

Source DB:  PubMed          Journal:  Nouv Presse Med        ISSN: 0301-1518


  2 in total

Review 1.  Advances in the management of digoxin toxicity in the older patient.

Authors:  S W Borron; C Bismuth; J Muszynski
Journal:  Drugs Aging       Date:  1997-01       Impact factor: 3.923

2.  Acute occlusion of the celiac axis and its branches with perforation of gastric fundus and splenic infarction, findings on spiral computed tomography: a case report.

Authors:  Nikolaos L Kelekis; Evangelos Athanassiou; Dimitra Loggitsi; Rebecca Moisidou; George Tzovaras; Ioannis Fezoulidis
Journal:  Cases J       Date:  2010-03-22
  2 in total

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