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Literature DB >> 6972838

T lymphocyte mobility: defects and effects of ascorbic acid, histamine and complexed IgG.

E M Smogorzewska, L Layward, J F Soothill.

Abstract

T lymphocyte mobility is low in patients with low neutrophil mobility. Thymocytes move comparably with normal mature T lymphocytes. Histamine accelerates T lymphocyte mobility in healthy subjects, patients with defective lymphocyte mobility and thymocytes. Ascorbic acid increases lymphocyte mobility of healthy subjects and thymocytes. Inhibition of mobility of T- or Tmu-depleted T lymphocytes by complexed IgG casts doubt on previous reports that the T gamma cells do not move.

Entities: Chemical Species

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Year: 1981 PMID： 6972838 PMCID： PMC1537138

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

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References

12 in total

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Authors: H R Hill; P G Quie
Journal: Lancet Date: 1974-02-09 Impact factor: 79.321

T lymphocyte mobility: defects and effects of ascorbic acid, histamine and complexed IgG.

1. Anti-Ig-triggered movements of lymphocytes-specificity and lack of evidence for directional migration.

2. Heterogeneity of locomotion in human T cell subsets.

3. Fc-receptor heterogeneity of human suppressor T cells.

4. Locomotion of human lymphoid cells. I. Effect of culture and con A on T and non-T lymphocytes.

5. Histamine receptor-bearing T lymphocytes in patients with allergy, autoimmune disease, or recurrent infection.

6. Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections.

7. Clinicopathological findings in patients with primary and secondary defects of neutrophil mobility.

8. An inherited defect of neutrophil mobility in Shwachman syndrome.

9. High incidence of undetected neoplasia in maldescended testes.

10. Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate.