| Literature DB >> 6972218 |
W B Sheldon, D P Lurie, H R Maricq, M B Kahaleh, F A DeLustro, A Gibofsky, E C LeRoy.
Abstract
A kindred is reported which contains 3 siblings with scleroderma, 2 siblings with Raynaud's phenomenon, and 2 first-degree relatives with histories suggestive of connective tissue syndromes. Studies of microvascular morphology and flow, serum endothelial cytotoxic activity, antinuclear antibodies, and HLA haplotypes in 18 relatives and 6 spouses revealed that 4 of 5 affected siblings expressed the HLA-DRw4 antigen, which was also present in 2 of 3 asymptomatic relatives whose serum contained endothelial cytotoxic activity. The evidence for an inherited susceptibility to scleroderma is reviewed.Entities:
Mesh：
Substances：
Year: 1981 PMID： 6972218 DOI： 10.1002/art.1780240507
Source DB: PubMed Journal: Arthritis Rheum ISSN： 0004-3591