Literature DB >> 6971096

Indoleamine 2,3-dioxygenase. A new, rapid, sensitive radiometric assay and its application to the study of the enzyme in rat tissues.

J S Cook, C I Pogson, S A Smith.   

Abstract

A simple and convenient assay for indoleamine 2,3-dioxygenase has been developed. This depends on the conversion of D-[ring-2-14C]tryptophan to [14C]formate, excess substrate is removed by adsorption onto charcoal. This assay, which is 20-fold more sensitive than previous procedures, is applicable both to crude extracts and to large numbers of samples. Activity in rat tissues is very much lower than in those of the rabbit; measureable activity is found only in the stomach, spleen, intestine and kidney. Enzyme activity in the rat intestine was increased by 50% in rats pretreated with L-tryptophan.

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Year:  1980        PMID： 6971096      PMCID： PMC1162025          DOI： 10.1042/bj1890461

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  15 in total

1.  Indoleamine 2,3-dioxygenase. Potassium superoxide as substrate.

Authors:  T Ohnishi; F Hirata; O Hayaish
Journal:  J Biol Chem       Date:  1977-07-10       Impact factor: 5.157

2.  Indoleamine 2,3-dioxygenase. Characterization and properties of enzyme. O2- complex.

Authors:  F Hirata; T Ohnishi; O Hayaishi
Journal:  J Biol Chem       Date:  1977-07-10       Impact factor: 5.157

3.  In vitro and in vivo formation of two new metabolites of melatonin.

Authors:  F Hirata; O Hayaishi; T Tokuyama; S Seno
Journal:  J Biol Chem       Date:  1974-02-25       Impact factor: 5.157

4.  The pyrrole ring cleavaging enzyme of 5-hydroxytryptophan.

Authors:  N Konishi; T Noguchì; R Kido
Journal:  Life Sci II       Date:  1971-04-22

5.  Use of a new radioassay for tryptophan oxygenase to study the development of the enzyme in chick embryos.

Authors:  B Peterkofsky
Journal:  Arch Biochem Biophys       Date:  1968-12       Impact factor: 4.013

6.  Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate.

Authors:  F Hirata; O Hayaishi
Journal:  J Biol Chem       Date:  1975-08-10       Impact factor: 5.157

7.  Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes.

Authors:  S Yamamoto; O Hayaishi
Journal:  J Biol Chem       Date:  1967-11-25       Impact factor: 5.157

8.  The activity of phosphoenolpyruvate carboxykinase in rat tissues. Assay techniques and effects of dietary and hormonal changes.

Authors:  C I Pogson; S A Smith
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

9.  Resolution of DL-tryptophan by affinity chromatography on bovine-serum albumin-agarose columns.

Authors:  K K Stewart; R F Doherty
Journal:  Proc Natl Acad Sci U S A       Date:  1973-10       Impact factor: 11.205

10.  Enzymic formation of D-kynurenine from D-tryptophan.

Authors:  K Higuchi; O Hayaishi
Journal:  Arch Biochem Biophys       Date:  1967-05       Impact factor: 4.013
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  10 in total

1.  Indoleamine 2,3-dioxygenase activity in the aqueous humor, iris/ciliary body, and retina of the bovine eye.

Authors:  H Z Malina; X D Martin
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1993-08       Impact factor: 3.117

2.  Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme.

Authors:  F Yamazaki; T Kuroiwa; O Takikawa; R Kido
Journal:  Biochem J       Date:  1985-09-15       Impact factor: 3.857

Review 3.  IDO and TDO as a potential therapeutic target in different types of depression.

Authors:  Yanjie Qin; Nanxi Wang; Xinlin Zhang; Xuemei Han; Xuejia Zhai; Yongning Lu
Journal:  Metab Brain Dis       Date:  2018-07-16       Impact factor: 3.584

4.  Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

Authors:  Y Ozaki; M P Edelstein; D S Duch
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

5.  Indoleamine 2, 3-dioxygenase (IDO) increases during renal fibrogenesis and its inhibition potentiates TGF-β 1-induced epithelial to mesenchymal transition.

Authors:  Luiz Henrique Gomes Matheus; Gislene Mendes Simão; Taíssa Altieri Amaral; Rodrigo Barbosa Oliveira Brito; Camila Soares Malta; Yves Silva Teles Matos; Alexandre Chagas Santana; Gabriela Gomes Cardoso Rodrigues; Maria Clara Albejante; Erna Elisabeth Bach; Maria Aparecida Dalboni; Cleber Pinto Camacho; Humberto Dellê
Journal:  BMC Nephrol       Date:  2017-09-06       Impact factor: 2.388

Review 6.  Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects.

Authors:  Abdulla A-B Badawy
Journal:  Int J Tryptophan Res       Date:  2017-03-15

7.  Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase.

Authors:  Derin B Keskin; Brendan Marshall; David Munn; Andrew L Mellor; Debra A Gearhart
Journal:  Cell Mol Biol Lett       Date:  2006-11-13       Impact factor: 5.787

Review 8.  Tryptophan Metabolism via Kynurenine Pathway: Role in Solid Organ Transplantation.

Authors:  Ruta Zulpaite; Povilas Miknevicius; Bettina Leber; Kestutis Strupas; Philipp Stiegler; Peter Schemmer
Journal:  Int J Mol Sci       Date:  2021-02-15       Impact factor: 5.923

Review 9.  Tryptophan metabolism, disposition and utilization in pregnancy.

Authors:  Abdulla A-B Badawy
Journal:  Biosci Rep       Date:  2015-09-17       Impact factor: 3.840

Review 10.  An Expanded Neuroimmunomodulation Axis: sCD83-Indoleamine 2,3-Dioxygenase-Kynurenine Pathway and Updates of Kynurenine Pathway in Neurologic Diseases.

Authors:  Li Bo; Tan Guojun; Guo Li
Journal:  Front Immunol       Date:  2018-06-15       Impact factor: 7.561
  10 in total

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