Literature DB >> 6970230

Biochemical separation of interleukin 2.

D Y Mochizuki, J Watson, S Gillis.   

Abstract

Interleukin 2 (IL-2) is a class of T cell growth factors produced by T cells of a number of species. The unique growth-promoting properties of these molecules allow the development of antigen-specific effector T cell lines which can be used to analyze the molecular basis of lymphocyte interactions. A murine T cell tumor line has been identified as a source of IL-2. The purification and biochemical properties of murine IL-2 are described, and compared with rat and human Il-2.

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Year:  1980        PMID： 6970230     DOI： 10.1016/0022-1759(80)90055-1

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  5 in total

1.  Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2.

Authors:  M A Cheever; P D Greenberg; A Fefer; S Gillis
Journal:  J Exp Med       Date:  1982-04-01       Impact factor: 14.307

2.  In vivo modulation of thymus-derived lymphocytes with monoclonal antibodies in mice. III. Spontaneous and natural cytotoxic effector cells.

Authors:  A G Herbert; G S Le Gros; S Bidawid; J D Watson
Journal:  Immunology       Date:  1984-02       Impact factor: 7.397

3.  Colony formation by subpopulations of T lymphocytes. IV. Inhibitory effect of hydrocortisone on human and murine T cell subsets.

Authors:  M H Claësson; C Röpke
Journal:  Clin Exp Immunol       Date:  1983-11       Impact factor: 4.330

Review 4.  Interleukin 2: biology and biochemistry.

Authors:  S Gillis
Journal:  J Clin Immunol       Date:  1983-01       Impact factor: 8.317

Review 5.  Utilizing Immunocytokines for Cancer Therapy.

Authors:  Erin Runbeck; Silvia Crescioli; Sophia N Karagiannis; Sophie Papa
Journal:  Antibodies (Basel)       Date:  2021-03-09
  5 in total

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