| Literature DB >> 6969374 |
H P Von Hahn, C G Honegger, A Pletscher.
Abstract
Blood platelets and brain membranes of SIV and Lewis rats both exhibited two saturable binding sites for 5-hydroxytryptamine (5-HT) in the concentration range 1-100 nM. The Kd values for the high-affinity sites were 4-6 nM and for the low-affinity sites 20-40 nM in both tissues of both rat strains. Blood platelets had 100-200 times more binding sites per mg protein (Bmax) than brain membranes. Thus, 5-HT receptors of platelets may be used as models for those of cerebral 5-HT-neurons.Entities:
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Year: 1980 PMID： 6969374 DOI： 10.1016/0304-3940(80)90167-6
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046