Literature DB >> 6969215

Antibody-dependent cellular cytotoxicity mediated by subpopulations of human T lymphocytes: killing of human erythrocytes and autologous lymphoid cells.

P Katz, A S Fauci.   

Abstract

The present study characterized the cytotoxic capabilities of human T lymphocyte subpopulations against human red blood cells (HRBC) and autologous lymphoid cells in an antibody-dependent cellular cytotoxicity (ADCC) assay. T cells bearing Fc receptors for immunoglobulin IgG (TG) were capable of lysis of antibody-coated HRBC and autologous lymphoid cells while T cells with surface Fc receptors for IgM (TM) displayed no ADCC activity TG-cell mediated ADCC could be inhibited by blockage of surface Fc receptors following treatment with aggregated Ig. Null cells and low-affinity E-rosette forming cells were also capable of similar ADCC activity against these targets.

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Year:  1980        PMID： 6969215      PMCID： PMC1457808     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  22 in total

1.  Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells.

Authors:  M Ferrarini; L Moretta; R Abrile; M L Durante
Journal:  Eur J Immunol       Date:  1975-01       Impact factor: 5.532

2.  Expression of a receptor for IgM by human T cells in vitro.

Authors:  L Moretta; M Ferrarini; M L Durante; M C Mingari
Journal:  Eur J Immunol       Date:  1975-08       Impact factor: 5.532

3.  Temporary inhibition of antibody-dependent, cell-mediated cytotoxicity by pretreatment of human attacking cells with ammonium chloride.

Authors:  I Yust; R W Smith; J R Wunderlich; D L Mann
Journal:  J Immunol       Date:  1976-04       Impact factor: 5.422

4.  Human bone marrow lymphocytes. Cytotoxic effector cells in the bone marrow of normal individuals.

Authors:  A S Fauci; J E Balow; K R Pratt
Journal:  J Clin Invest       Date:  1976-04       Impact factor: 14.808

5.  Haemolytic activity of human blood monocytes. Lysis of human erythrocytes treated with anti-A serum.

Authors:  G Holm; S Hammarström
Journal:  Clin Exp Immunol       Date:  1973-01       Impact factor: 4.330

6.  Activation of human B lymphocytes. II. Cellular interactions in the PFC response of human tonsillar and peripheral blood B lymphocytes to polyclonal activation by pokeweed mitogen.

Authors:  A S Fauci; K R Pratt; G Whalen
Journal:  J Immunol       Date:  1976-12       Impact factor: 5.422

7.  Antibody-dependent cell-mediated cytotoxicity: heterogeneity of effector cells in human peripheral blood.

Authors:  H R MacDonald; G D Bonnard; B Sordat; S A Zawodnik
Journal:  Scand J Immunol       Date:  1975-09       Impact factor: 3.487

8.  Activation of human B lymphocytes. I. Direct plaque-forming cell assay for the measurement of polyclonal activation and antigenic stimulation of human B lymphocytes.

Authors:  A S Fauci; K R Pratt
Journal:  J Exp Med       Date:  1976-09-01       Impact factor: 14.307

9.  Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG.

Authors:  L Moretta; S R Webb; C E Grossi; P M Lydyard; M D Cooper
Journal:  J Exp Med       Date:  1977-07-01       Impact factor: 14.307

10.  Studies of the human lymphocyte receptor for heat-aggregated or antigen-complexed immunoglobulin.

Authors:  H B Dickler
Journal:  J Exp Med       Date:  1974-08-01       Impact factor: 14.307
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