Literature DB >> 696859

Secretory effects of VIP on isolated perfused porcine pancreas.

S L Jensen, J Fahrenkrug, J J Holst, O V Nielsen, O B Schaffalitzky de Muckadell.   

Abstract

We studied the secretion of insulin, glucagon, and the exocrine secretion of the isolated perfused porcine pancreas in response to vasoactive intestinal polypeptide (VIP) in concentrations ranging from 30 to 18,750 pmol/liter at various concentrations of glucose in the perfusion medium. VIP stimulated the insulin and glucagon secretion in a dose-dependent manner. The response pattern was critically dependent on the glucose concentration. In the presence of a glucose concentration of 7.5 mmol/liter, VIP enhanced insulin release without affecting glucagon release. Maximal insulin release was obtained at a VIP concentration of 3,750 pmol/liter. At a glucose concentration of 5.0 or 3.5 mmol/liter, VIP enhanced glucagon release but not insulin release. VIP stimulated the exocrine secretion in a secretin-like manner. The lowest concentration of VIP observed to increase pancreatic exocrine secretion was 30 pmol/liter, whereas the maximal pancreatic exocrine responses were not obtained.

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Year:  1978        PMID： 696859     DOI： 10.1152/ajpendo.1978.235.4.E387

Source DB:  PubMed          Journal:  Am J Physiol        ISSN： 0002-9513


  13 in total

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7.  The location of VIP in the pancreas of man and rat.

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8.  Primary Pancreatic Secretinoma: Further Evidence Supporting Secretin as a Diarrheogenic Hormone.

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10.  Effects of vasoactive intestinal polypeptide (VIP), secretin and gastrin on insulin secretion in the mouse.

Authors:  B Ahrén; I Lundquist
Journal:  Diabetologia       Date:  1981       Impact factor: 10.122
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