| Literature DB >> 6968248 |
L Y Bourguignon, K Balazovich.
Abstract
The antidepressant agent, Stelazine (trifluoroperazine dihydrochloride), is known to cause inactivation of the calcium-binding protein, calmodulin. We report here that this drug in the concentration range of 5 x 10(-5) M to 10(-6) M causes remarkable inhibitory effets on ligand-induced T-lymphocyte receptor capping. The possible involvement of calmodulin in the regulation of lymphocyte surface receptor movement is therefore implicated.Entities:
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Year: 1980 PMID： 6968248 DOI： 10.1016/0309-1651(80)90197-6
Source DB: PubMed Journal: Cell Biol Int Rep ISSN： 0309-1651