Literature DB >> 6967495

Sunscreens prevent ultraviolet photocarcinogenesis.

L H Kligman, F J Akin, A M Kligman.   

Abstract

Sunscreens of low or high sun protection factors (SPF*) were tested for their ability to inhibit ultraviolet (UV) carcinogenesis in two varieties of hairless mice. Low protection (SPF = 2) reduced by 50% the number of albino animals developing tumors. High protection (SPF =15) prevented tumor formation. Tumorigenesis was totally prevented in the lightly pigmented variety with either sunscreen, demonstrating the added protection of melanin. In mice and man, UV-induced cancer is a cumulative process. Reducing the amount of UV light reaching the basal layer will retard that process.

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Year:  1980        PMID： 6967495     DOI： 10.1016/s0190-9622(80)80221-0

Source DB:  PubMed          Journal:  J Am Acad Dermatol        ISSN： 0190-9622            Impact factor:   11.527


  13 in total

Review 1.  [Sunscreens. Protection against skin cancers and photoaging].

Authors:  P Wolf
Journal:  Hautarzt       Date:  2003-09       Impact factor: 0.751

2.  Could sunscreens increase melanoma risk?

Authors:  C F Garland; F C Garland; E D Gorham
Journal:  Am J Public Health       Date:  1992-04       Impact factor: 9.308

Review 3.  Green tea prevents non-melanoma skin cancer by enhancing DNA repair.

Authors:  Santosh K Katiyar
Journal:  Arch Biochem Biophys       Date:  2010-11-19       Impact factor: 4.013

4.  Dermatology-important advances in clinical medicine: sunscreens.

Authors:  N J Lowe
Journal:  West J Med       Date:  1983-06

5.  The inhibiting effect of PABA on photocarcinogenesis.

Authors:  H Flindt-Hansen; P Thune; T E Larsen
Journal:  Arch Dermatol Res       Date:  1990       Impact factor: 3.017

6.  [UV radiation and skin pigmentation. Aryl hydrocarbon receptor - a "new kid on the block"].

Authors:  C Esser; J Krutmann
Journal:  Hautarzt       Date:  2010-07       Impact factor: 0.751

Review 7.  Common cutaneous disorders in athletes.

Authors:  R J Conklin
Journal:  Sports Med       Date:  1990-02       Impact factor: 11.136

Review 8.  Grape seed proanthocyanidines and skin cancer prevention: inhibition of oxidative stress and protection of immune system.

Authors:  Santosh K Katiyar
Journal:  Mol Nutr Food Res       Date:  2008-06       Impact factor: 5.914

Review 9.  Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms.

Authors:  Joi A Nichols; Santosh K Katiyar
Journal:  Arch Dermatol Res       Date:  2009-11-07       Impact factor: 3.017

10.  Lack of enhancement of experimental photocarcinogenesis by topical retinoic acid.

Authors:  L H Kligman; A M Kligman
Journal:  Arch Dermatol Res       Date:  1981       Impact factor: 3.017
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