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Literature DB >> 6967214

Immunologic effects of whole-body ultraviolet irradiation: selective defect in splenic adherent cell function in vitro.

N L Letvin, M I Greene, B Benacerraf, R N Germain.

Abstract

Splenocytes from mice receiving whole-body UV irradiation do not make a normal primary in vitro plaque-forming cell (PFC) response to the soluble T-dependent antigen trinitrophenylated poly(L-glutamic acid60L-alanine30L-tyrosine10). This impaired immune response results from a selective loss of antigen-presenting cell function in the splenic adherent cell (SAC) population of the UV-treated mice. SACs from UV-irradiated mice are unable to reconstitute a PFC response when added to normal splenocytes passed through Sephadex G-10 (which depletes adherent cells), whereas normal SACs, when added to Sephadex G-10-passed splenocytes from UV-treated mice, do restore a PFC response. The effect of in vivo UV irradiation on the SAC population is indistinguishable functionally from the effect of in vitro UV irradiation of SACs from normal mice. Possible explanations for this selective effect of external UV irradiation on SAC function are discussed.

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Year: 1980 PMID： 6967214 PMCID： PMC349509 DOI： 10.1073/pnas.77.5.2881

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

20 in total

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Authors: G Möller; H Lemke; H G Opitz
Journal: Scand J Immunol Date: 1976 Impact factor: 3.487

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Authors: M L Kripke
Journal: J Reticuloendothel Soc Date: 1977-09

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Authors: I A Ly; R I Mishell
Journal: J Immunol Methods Date: 1974-08 Impact factor: 2.303

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Authors: M Hoffmann; R W Dutton
Journal: Science Date: 1971-06-04 Impact factor: 47.728

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Authors: M B Rittenberg; K L Pratt
Journal: Proc Soc Exp Biol Med Date: 1969-11

6. Antigen-bearing langerhans cells in skin, dermal lymphatics and in lymph nodes.

Authors: I Silberberg-Sinakin; G J Thorbecke; R L Baer; S A Rosenthal; V Berezowsky
Journal: Cell Immunol Date: 1976-08 Impact factor: 4.868

7. Immunologic parameters of ultraviolet carcinogenesis.

Authors: M L Kripke; M S Fisher
Journal: J Natl Cancer Inst Date: 1976-07 Impact factor: 13.506

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Authors: C Chen; J G Hirsch
Journal: J Exp Med Date: 1972-09-01 Impact factor: 14.307

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Authors: E M Shevach; W E Paul; I Green
Journal: J Exp Med Date: 1972-11-01 Impact factor: 14.307

10. Immunization of dissociated spleen cell cultures from normal mice.

Authors: R I Mishell; R W Dutton
Journal: J Exp Med Date: 1967-09-01 Impact factor: 14.307

16 in total

1. Circulating suppressor factors in mice subjected to ultraviolet irradiation and contact sensitization.

Authors: T G Harriott-Smith; W J Halliday
Journal: Immunology Date: 1986-02 Impact factor: 7.397

2. Reduced antigen-presenting function of human Epstein-Barr virus (EBV)-B cells and monocytes after UVB radiation is accompanied by decreased expression of B7, intercellular adhesion molecule-1 (ICAM-1) and LFA-3.

Authors: I B Kremer; J D Bos; B M Teunissen
Journal: Clin Exp Immunol Date: 1995-09 Impact factor: 4.330

Review 3. Advances in the immunobiology of the skin. Implications for cutaneous malignancies.

Authors: C A Romerdahl; M L Kripke
Journal: Cancer Metastasis Rev Date: 1986 Impact factor: 9.264

4. Ultraviolet light-induced suppression of antigen presentation.

Authors: C W Spellman; T B Tomasi
Journal: J Clin Immunol Date: 1983-04 Impact factor: 8.317

5. Suppression of contact hypersensitivity by ultraviolet radiation: an experimental model.

Authors: F P Noonan; E C De Fabo; M L Kripke
Journal: Springer Semin Immunopathol Date: 1981

6. B-lymphocyte responses to trinitrophenyl-conjugated Ficoll: requirement for T lymphocytes and Ia-bearing adherent cells.

Authors: N L Letvin; B Benacerraf; R N Germain
Journal: Proc Natl Acad Sci U S A Date: 1981-08 Impact factor: 11.205

7. Antigen-presenting cell function in induction of helper T cells for cytotoxic T-lymphocyte responses: evidence for antigen processing.

Authors: O Weinberger; S Herrmann; M F Mescher; B Benacerraf; S J Burakoff
Journal: Proc Natl Acad Sci U S A Date: 1981-03 Impact factor: 11.205

8. Prolongation of skin graft survival in mice by in vitro PUVA treatment and failure of induction of specific immunological memory by PUVA-treated grafts.

Authors: S Gruner; H Meffert; E Karasek; N Sönnichsen
Journal: Arch Dermatol Res Date: 1984 Impact factor: 3.017

9. Cell-mediated immune responses to syngeneic ultraviolet-induced tumours. V. Assessment of accessory and antigen-presenting cell capabilities of normal and ultraviolet-irradiated mice in the generation of anti-tumour cytotoxic effector cells in vitro.

Authors: D H Lynch; M F Gurish; R A Daynes
Journal: Immunology Date: 1982-09 Impact factor: 7.397

10. Systemic suppression of contact hypersensitivity by UVB radiation is unrelated to the UVB-induced alterations in the morphology and number of Langerhans cells.

Authors: W L Morison; C Bucana; M L Kripke
Journal: Immunology Date: 1984-06 Impact factor: 7.397