Literature DB >> 6966936

The effect of methotrexate and hydroxyurea on neutrophil chemotaxis.

J J Cream, D S Pole.   

Abstract

Methotrexate depresses motility of neutrophils in chamber membranes, but does not interfere with random motility in tubes. Hydroxyurea has no such effect. The therapeutic response to methotrexate in psoriasis may be due in part to a reduction in migration of neutrophils into the epidermis.

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Year:  1980        PMID： 6966936     DOI： 10.1111/j.1365-2133.1980.tb07655.x

Source DB:  PubMed          Journal:  Br J Dermatol        ISSN： 0007-0963            Impact factor:   9.302


  6 in total

Review 1.  Molecular mechanism of methotrexate action in inflammation.

Authors:  B N Cronstein
Journal:  Inflammation       Date:  1992-10       Impact factor: 4.092

2.  Inhibition of neutrophil chemotaxis in methotrexate-treated rheumatoid arthritis patients.

Authors:  J W O'Callaghan; M J Forrest; P M Brooks
Journal:  Rheumatol Int       Date:  1988       Impact factor: 2.631

Review 3.  Corticosteroid sparing agents in asthma.

Authors:  J M Hill; A E Tattersfield
Journal:  Thorax       Date:  1995-05       Impact factor: 9.139

4.  Pyoderma gangrenosum in acute myeloid leukaemia during immunosuppression.

Authors:  P C van de Kerkhof; G A de Vaan; R Holland
Journal:  Eur J Pediatr       Date:  1988-10       Impact factor: 3.183

5.  Interleukin-8 in inflammatory rheumatic diseases: synovial fluid levels, relation to rheumatoid factors, production by mononuclear cells, and effects of gold sodium thiomalate and methotrexate.

Authors:  M Seitz; B Dewald; M Ceska; N Gerber; M Baggiolini
Journal:  Rheumatol Int       Date:  1992       Impact factor: 2.631

6.  Colchicine and methotrexate reduce leukocyte adherence and emigration in rat mesenteric venules.

Authors:  H Asako; P Kubes; B A Baethge; R E Wolf; D N Granger
Journal:  Inflammation       Date:  1992-02       Impact factor: 4.092
  6 in total

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