Literature DB >> 6966895

Health status of cable splicers with low-level exposure to lead: results of a clinical survey.

A Fischbein, J Thornton, W E Blumberg, J Bernstein, J A Valciukas, M Moses, B Davidow, B Kaul, M Sirota, I J Selikoff.   

Abstract

The results of a cross-sectional clinical field survey of 90 telephone cable splicers are presented. Despite the rare occurrence of clinically overt lead poisoning among cable splicers, the observed prevalence of symptoms was 29% for lead-associated central nervous system symptoms and 21% for gastrointestinal symptoms. These two groups of symptoms were directly related to zinc protoporphyrin (ZPP) levels but no relationship was found between them and blood lead concentrations. Only 5% of the workers had significantly elevated blood lead levels (greater than 40 microgram/100ml). Because of the intermittent lead exposure encountered in this trade, individuals were identified with "normal" blood lead levels associated with "elevated" zinc protoporphyrin concentrations, indicating the difference in biological significance between exposure-(blood lead) and biological-response tests (ZPP). Suggestion is made that both types of diagnostic tests be utilized in the medical surveillance of lead-exposured workers.

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Year:  1980        PMID: 6966895      PMCID: PMC1619483          DOI: 10.2105/ajph.70.7.697

Source DB:  PubMed          Journal:  Am J Public Health        ISSN: 0090-0036            Impact factor:   9.308


  21 in total

1.  Erythropoietic protoporphyria and lead intoxication: the molecular basis for difference in cutaneous photosensitivity. II. Different binding of erythrocyte protoporphyrin to hemoglobin.

Authors:  A A Lamola; S Piomelli; M G Poh-Fitzpatrick; T Yamane; L C Harber
Journal:  J Clin Invest       Date:  1975-12       Impact factor: 14.808

2.  Subclinical neuropathy at "safe" levels of lead exposure.

Authors:  A M Seppäläinen; S Tola; S Hernberg; B Kock
Journal:  Arch Environ Health       Date:  1975-04

3.  Free erythrocyte protoporphyrin as an indicator of the biological effect of lead in adult males. I. Relationship between free erythrocyte protoporphyrin and indicators of internal dose of lead.

Authors:  L Alessio; P A Bertazzi; F Toffoletto; V Foà
Journal:  Int Arch Occup Environ Health       Date:  1976-06-03       Impact factor: 3.015

Review 4.  Lead and the kidney.

Authors:  R A Goyer
Journal:  Curr Top Pathol       Date:  1971

5.  Subclinical neuropathy in lead workers.

Authors:  M J Catton; M J Harrison; P M Fullerton; G Kazantzis
Journal:  Br Med J       Date:  1970-04-11

6.  Studies in lead poisoning. I. Microanalysis of erythrocyte protoporphyrin levels by spectrophotometry in the detection of chronic lead intoxication in the subclinical range.

Authors:  S Sassa; J L Granick; S Granick; A Kappas; R D Levere
Journal:  Biochem Med       Date:  1973-08

7.  Management of an autistic child undergoing open heart surgery.

Authors:  H P Gabriel; R Gluck
Journal:  Pediatrics       Date:  1973-02       Impact factor: 7.124

8.  Nephropathy in chronic lead poisoning.

Authors:  R Lilis; N Gavrilescu; B Nestorescu; C Dumitriu; A Roventa
Journal:  Br J Ind Med       Date:  1968-07

9.  Zinc protoporphyrin in the erythrocytes of patients with lead intoxication and iron deficiency anemia.

Authors:  A A Lamola; T Yamane
Journal:  Science       Date:  1974-12-06       Impact factor: 47.728

10.  Role of chronic low-level lead exposure in the aetiology of mental retardation.

Authors:  A D Beattie; M R Moore; M J Finlayson; J F Graham; E M Mackie; J C Main; D A McLaren; K M Murdoch; G T Steward
Journal:  Lancet       Date:  1975-03-15       Impact factor: 79.321

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  1 in total

1.  Past asbestos exposure among cable splicers.

Authors:  A Fischbein; A N Rohl; A M Langer; I J Selikoff
Journal:  Am J Public Health       Date:  1981-11       Impact factor: 9.308

  1 in total

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