Literature DB >> 6965699

The activity of partially purified leukocytic endogenous mediator in endotoxin-resistant C3H/HeJ mice.

R F Kampschmidt, L A Pulliam, H F Upchurch.   

Abstract

Partially purified LEM was injected into both the endotoxin-resistant C3H/HeJ and the closely related, but endotoxin-responsive, C3Heb/FeJ strains of mice. Both strains of mice responded to LEM with significant decreases in plasma iron concentration, increased number of peripheral blood neutrophils, increased plasma levels of CSA, and elevations of plasma fibrinogen concentration. Injections of endotoxin produced significant responses in these four determinations in C3Heb/FeJ mice but had no effect in the C3H/HeJ strain. Changes in plasma iron, fibrinogen, CSA, and neutrophils are believed to occur when LEM is produced by an interaction of endotoxin with phagocytic cells.

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Year:  1980        PMID： 6965699

Source DB:  PubMed          Journal:  J Lab Clin Med        ISSN： 0022-2143


  15 in total

1.  Prognostic significance of serum iron levels in cases of Japanese encephalitis.

Authors:  M Bharadwaj; V Prakash; A Mathur; U C Chaturvedi
Journal:  Postgrad Med J       Date:  1991-03       Impact factor: 2.401

2.  Effect of ultraviolet radiation on production of epidermal cell thymocyte-activating factor/interleukin 1 in vivo and in vitro.

Authors:  L Gahring; M Baltz; M B Pepys; R Daynes
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

3.  Increased thymocyte-activating factor in human gingival fluid during gingival inflammation.

Authors:  J A Charon; T A Luger; S E Mergenhagen; J J Oppenheim
Journal:  Infect Immun       Date:  1982-12       Impact factor: 3.441

4.  Effect of macrophage-derived factor on hypoferraemia induced by Japanese encephalitis virus in mice.

Authors:  M Bharadwaj; N Khanna; A Mathur; U C Chaturvedi
Journal:  Clin Exp Immunol       Date:  1991-02       Impact factor: 4.330

5.  Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones.

Authors:  D M Durnam; J S Hoffman; C J Quaife; E P Benditt; H Y Chen; R L Brinster; R D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

6.  Inflammation triggers hypoferremia and de novo synthesis of serum transferrin and ceruloplasmin in mice.

Authors:  D L Beaumier; M A Caldwell; B E Holbein
Journal:  Infect Immun       Date:  1984-11       Impact factor: 3.441

7.  Experimental model of ischemic bowel necrosis. The role of platelet-activating factor and endotoxin.

Authors:  F Gonzalez-Crussi; W Hsueh
Journal:  Am J Pathol       Date:  1983-07       Impact factor: 4.307

8.  Turnover in the transferrin iron pool during the hypoferremic phase of experimental Neisseria meningitidis infection in mice.

Authors:  E D Letendre; B E Holbein
Journal:  Infect Immun       Date:  1983-01       Impact factor: 3.441

9.  Further comparisons of endogenous pyrogens and leukocytic endogenous mediators.

Authors:  R F Kampschmidt; H F Upchurch; M L Worthington
Journal:  Infect Immun       Date:  1983-07       Impact factor: 3.441

10.  Role of interleukin-1 in the depression of liver drug metabolism by endotoxin.

Authors:  P Ghezzi; B Saccardo; P Villa; V Rossi; M Bianchi; C A Dinarello
Journal:  Infect Immun       Date:  1986-12       Impact factor: 3.441
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