Literature DB >> 6965661

Serum levels of alpha-1-antitrypsin in individuals with different Pi M subtypes.

G Beckman, L Beckman.   

Abstract

Individuals with heterozygous Pi M subtypes were found to have higher serum levels of alpha 1-antitrypsin (alpha 1-AT) than homozygotes. The alpha 1-AT levels in heterozygotes showed a unimodal distribution. Among homozygotes, a tendency towards a bimodal distribution was found. The mechanism behind this difference is not known. The result can apparently not be explained as the result of a hitherto undiscovered deficiency gene.

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Year:  1980        PMID： 6965661     DOI： 10.1159/000153106

Source DB:  PubMed          Journal:  Hum Hered        ISSN： 0001-5652            Impact factor:   0.444


  3 in total

1.  Does the PI polymorphism alone control alpha-1-antitrypsin expression?

Authors:  N G Martin; P Clark; A F Ofulue; L J Eaves; L A Corey; W E Nance
Journal:  Am J Hum Genet       Date:  1987-03       Impact factor: 11.025

2.  Genetic regulation of alpha-1-antitrypsin levels in the neonatal period: the influence of the PiS allele and the PiM subtypes.

Authors:  P Auconi; R Biagini; R Donnini; A Fabiano; D Ragusa; G Massi
Journal:  Eur J Pediatr       Date:  1981-05       Impact factor: 3.183

3.  Polymorphism of alpha-1-antitrypsin in hematological malignancies.

Authors:  Aleksandra Topic; Zorica Juranic; Svetislav Jelic; Ivana Golubicic Magazinovic
Journal:  Genet Mol Biol       Date:  2009-12-01       Impact factor: 1.771
  3 in total

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