Literature DB >> 6965452

Deficiency of T cell mediated regulation of anti-DNA production in systemic lupus erythematosus.

J D Clough, S A Frank, L H Calabrese.   

Abstract

Isolated B cells from normal subjects and patients with systemic lupus erythematosus (SLE) could be stimulated to produce IgM anti-DNA with pokeweed mitogen. Normal but not SLE allogeneic T cells abrogated this response. Normal but not SLE autologous T cells promoted a switch from IgM to IgG anti-DNA production. SLE is characterized by at least two types of immunoregulatory abnormalities: a defect in T suppressor function and a defect in the IgM to IgG switchover.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 6965452     DOI： 10.1002/art.1780230105

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  9 in total

1.  Monocyte-mediated suppression of anti-DNA antibody production in healthy subjects.

Authors:  M Okawa-Takatsuji; S Aotsuka; S Uwatoko; M Kinoshita; R Yokohari
Journal:  Clin Exp Immunol       Date:  1989-09       Impact factor: 4.330

2.  Selective bone marrow involvement of lymphoplasmacytic cells secreting monoclonal IgA rheumatoid factor in a patient with Sjögren's syndrome and serum hyperviscosity.

Authors:  C Bergonzi; G P Merlini; S Morandi; E Bianchini; F Pavesi; V Bellotti; C M Montecucco; E Ascari
Journal:  Ann Rheum Dis       Date:  1987-12       Impact factor: 19.103

3.  Efficient generation in vitro, from human peripheral blood cells, of monoclonal Epstein-Barr virus transformants producing specific antibody to a variety of antigens without prior deliberate immunization.

Authors:  L Winger; C Winger; P Shastry; A Russell; M Longenecker
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

4.  IgG antibodies to SS-B (La), RNP/Sm and DNA are produced by PWM-stimulated normal human lymphocytes in culture.

Authors:  P Mumford; G R Room; P J Venables; R N Maini
Journal:  Rheumatol Int       Date:  1985       Impact factor: 2.631

5.  Follow-up of antibodies against single-stranded DNA in patients with haematological malignancies.

Authors:  A A Kostiala; M Gripenberg; E Elonen; G Gripenberg; I Kostiala
Journal:  Clin Exp Immunol       Date:  1985-07       Impact factor: 4.330

6.  D-penicillamine: a modulator of anti-DNA antibodies production.

Authors:  P S Mach; H Brouilhet; B Amor
Journal:  Clin Exp Immunol       Date:  1986-02       Impact factor: 4.330

7.  The effect of La(SSB) on PWM-induced immunoglobulin synthesis by anti-La(SSB) positive SLE patients and healthy controls.

Authors:  G Smith; C A Morrison; P J Maddison
Journal:  Clin Exp Immunol       Date:  1987-06       Impact factor: 4.330

8.  The in vitro production and regulation of anti-double stranded DNA antibodies by peripheral blood mononuclear cells from normals and patients with systemic lupus erythematosus.

Authors:  P S Mach; M Kharouby; F Lutcher; J L Olivier; N Bazely; M Dougados; B Amor
Journal:  Clin Exp Immunol       Date:  1984-08       Impact factor: 4.330

9.  Allogeneic suppression of polyclonal immunoglobulin production in normals and patients with systemic lupus erythematosus.

Authors:  J D Clough; R A Krakauer; S A Frank; L H Calabrese
Journal:  Clin Exp Immunol       Date:  1980-10       Impact factor: 4.330
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.