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Literature DB >> 6965386

Differentiation of Thy 1-bearing cells from progenitors in long-term bone marrow cultures.

E V Jones-Villeneuve, J J Rusthoven, R G Miller, R A Phillips.

Abstract

Lone-term marrow cultures, established according to the technique described by Dexter, contain a colony-forming cell (CFU-T) that produces Thy 1-positive progeny after stimulation with PHA-induced conditioned medium from human leukocytes. When 10(-7) M hydrocortisone is added to the medium for the long-term cultures CFU-T can be maintained in vitro for at least 16 weeks. Cells from individual colonies lack precursors for cytotoxic lymphocytes but can provide nonspecific help required for the generation of cytotoxic lymphocytes.

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Year: 1980 PMID： 6965386

Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422

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Cited

6 in total

4. Cells in bone marrow and in T cell colonies grown from bone marrow can suppress generation of cytotoxic T lymphocytes directed against their self antigens.

Authors: S Muraoka; R G Miller
Journal: J Exp Med Date: 1980-07-01 Impact factor: 14.307

5. Differentiation from precursors in athymic nude mouse bone marrow of unusual spontaneously cytolytic cells showing anti-self-H-2 specificity and bearing T cell markers.

Authors: J Reimann; R G Miller
Journal: J Exp Med Date: 1983-11-01 Impact factor: 14.307

6. Studies on the in vivo production of a lymphokine activity, interleukin 3 (IL-3) elaborated by lymphocytes and a myeloid leukaemic line in vitro and the fate of IL-3 dependent cell lines.

Authors: J M Garland; A Aldridge; J Wagstaffe; T M Dexter
Journal: Br J Cancer Date: 1983-08 Impact factor: 7.640

6 in total

Differentiation of Thy 1-bearing cells from progenitors in long-term bone marrow cultures.

1. Myelo-lymphopoiesis in long-term bone marrow culture.

2. Abnormal rearrangements of T-cell receptor genes occur in long-term cultured bone marrow cells of lpr/lpr mice.

3. Long-term culture of human bone marrow cells.

4. Cells in bone marrow and in T cell colonies grown from bone marrow can suppress generation of cytotoxic T lymphocytes directed against their self antigens.

5. Differentiation from precursors in athymic nude mouse bone marrow of unusual spontaneously cytolytic cells showing anti-self-H-2 specificity and bearing T cell markers.

6. Studies on the in vivo production of a lymphokine activity, interleukin 3 (IL-3) elaborated by lymphocytes and a myeloid leukaemic line in vitro and the fate of IL-3 dependent cell lines.