Literature DB >> 6965308

Suppression of T cells specific for the nonthymic parental H-2 haplotype in thymus-grafted chimeras.

F I Smith, J F Miller.   

Abstract

The mechanism of restriction of T-cell specificity by the genotype of the thymus in allogeneic and semiallogeneic chimeras was investigated. Lack of induction of delayed-type hypersensitivity (DTH) directed against antigen in association with the nonthymic parental haplotype in naive cells adoptively transferred into chimeras suggests the existence of an in vivo suppressive mechanism. However, it was not possible to suppress the expression of DTH in sensitized cells transferred into chimeras, or to transfer this suppression to normal naive recipients.

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Year:  1980        PMID： 6965308      PMCID： PMC2185764          DOI： 10.1084/jem.151.1.246

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  18 in total

1.  The function and interrelationships of T-cell receptors, Ir genes and other histocompatibility gene products.

Authors:  D H Katz; B Benacerraf
Journal:  Transplant Rev       Date:  1975

2.  Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.

Authors:  H von Boehmer; W Haas; N K Jerne
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

Review 3.  Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control.

Authors:  R M Zinkernagel
Journal:  Immunol Rev       Date:  1978       Impact factor: 12.988

Review 4.  Expression and function of idiotypes of lymphocytes.

Authors:  K Eichmann
Journal:  Adv Immunol       Date:  1978       Impact factor: 3.543

Review 5.  Two different VH gene products make up the T-cell receptors.

Authors:  C A Janeway; H Wigzell; H Binz
Journal:  Scand J Immunol       Date:  1976       Impact factor: 3.487

6.  A dual recognition model for cytotoxic T cells based on thymic selection of precursors with low affinity for Self H-2 antigens.

Authors:  R V Blanden; G L Ada
Journal:  Scand J Immunol       Date:  1978-03       Impact factor: 3.487

7.  Nature of the antigenic complex recognized by T lymphocytes: specific sensitization by antigens associated with allogeneic macrophages.

Authors:  D W Thomas; E M Shevach
Journal:  Proc Natl Acad Sci U S A       Date:  1977-05       Impact factor: 11.205

8.  The generation of killer cells to trinitrophenyl-modified allogeneic targets by lymphocyte populations negatively selected to strong alloantigens.

Authors:  D B Wilson; K F Lindahl; D H Wilson; J Sprent
Journal:  J Exp Med       Date:  1977-08-01       Impact factor: 14.307

9.  H-2 antigens of the thymus determine lymphocyte specificity.

Authors:  P J Fink; M J Bevan
Journal:  J Exp Med       Date:  1978-09-01       Impact factor: 14.307

10.  T cells specific for hapten-modified self are precommitted for self major histocompatibility complex antigens before encounter with the hapten.

Authors:  C A Janeway; P D Murphy; J Kemp; H Wigzell
Journal:  J Exp Med       Date:  1978-04-01       Impact factor: 14.307
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  8 in total

1.  Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.

Authors:  D L Longo; A M Kruisbeek; M L Davis; L A Matis
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

2.  Immunoreactivity of long lived H-2 incompatible irradiation chimeras (H-2d leads to H-2b).

Authors:  G J Maestroni; W Pierpaoli; R M Zinkernagel
Journal:  Immunology       Date:  1982-06       Impact factor: 7.397

Review 3.  T cell recognition of antigen in vivo: role of the H-2 complex.

Authors:  J Sprent; R Korngold; K Molnar-Kimber
Journal:  Springer Semin Immunopathol       Date:  1980-08

4.  Sendai virus-specific, H-2-restricted cytotoxic T lymphocyte responses of nude mice grafted with allogeneic or semi-allogeneic thymus glands.

Authors:  J P Lake; M E Andrew; C W Pierce; T J Braciale
Journal:  J Exp Med       Date:  1980-12-01       Impact factor: 14.307

5.  Restricted antibody formation to sheep erythrocytes of allogeneic bone marrow chimeras histoincompatible at the K end of the H-2 complex.

Authors:  K Onoé; R Yasumizu; T Oh-Ishi; M Kakinuma; R A Good; K Morikawa
Journal:  J Exp Med       Date:  1981-04-01       Impact factor: 14.307

6.  Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.

Authors:  N S Liao; J Maltzman; D H Raulet
Journal:  J Exp Med       Date:  1989-07-01       Impact factor: 14.307

7.  Frequency analysis of cytotoxic T lymphocyte precursors in chimeric mice. Evidence for intrathymic maturation of clonally distinct self-major histocompatibility complex- and allo-major histocompatiblilty complex-restricted virus-specific T cells.

Authors:  H Wagner; C Hardt; R Bartlett; H Stockinger; M Röllinghoff; H Rodt; K Pfizenmaier
Journal:  J Exp Med       Date:  1981-06-01       Impact factor: 14.307

8.  Role of the major histocompatibility gene products in regulating the antibody response to dinitrophenylated poly(L-Glu55,L-Ala35,L-Phe9)n.

Authors:  S K Pierce; N R Klinman; P H Maurer; C F Merryman
Journal:  J Exp Med       Date:  1980-08-01       Impact factor: 14.307
  8 in total

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