Impaired bone resorption of cultured calvaria from mice with abnormal lysosomal function (the Chediak-Higashi syndrome).

Spontaneous bone resorption is reduced in cultured calvarial bones from mice with the Chediak-Higashi syndrome, as indicated by decreased mobilization of calcium from the bones to the medium. Although bone resorption in calvaria from mice with this disease can be stimulated by PGE2 and 1 alpha (OH)D3, the amounts of mineral released after stimulation is also decreased.