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Literature DB >> 6964403

Sleep-promoting effects of muramyl peptides.

J M Krueger, J R Pappenheimer, M L Karnovsky.

Abstract

A muramyl peptide that induces excess slow-wave sleep in rats, rabbits, and cats has recently been isolated from human urine. We now report that synthetic acetylmuramyl-L-alanyl-D-isoglutamine ("muramyl dipeptide") and its lysyl derivative (acetylmuramyl-L-alanyl-D-isoglutaminyllysine) can mimic the somnogenic effects of the natural peptide. Both compounds are also pyrogenic and may cause other disturbances of autonomic function. The pyrogenic effects of intravenously administered muramyl dipeptide can be suppressed by previous treatment with acetaminophen without blocking the sleep-promoting effects.

Entities: Chemical Species

Mesh：

Substances：

Year: 1982 PMID： 6964403 PMCID： PMC347061 DOI： 10.1073/pnas.79.19.6102

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

12 in total

1. Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals.

Authors: J R Pappenheimer; G Koski; V Fencl; M L Karnovsky; J Krueger
Journal: J Neurophysiol Date: 1975-11 Impact factor: 2.714

2. "Nature's soft nurse": a sleep-promoting factor isolated from brain.

Authors: J R Pappenheimer
Journal: Johns Hopkins Med J Date: 1979-08

3. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.

Authors: F Ellouz; A Adam; R Ciorbaru; E Lederer
Journal: Biochem Biophys Res Commun Date: 1974-08-19 Impact factor: 3.575

4. Cerebral ventricular infusions in unrestrained rats.

Authors: C A Goodrich; B Greehey; T B Miller; J R Pappenheimer
Journal: J Appl Physiol Date: 1969-01 Impact factor: 3.531

Review 5. Synthetic immunostimulants derived from the bacterial cell wall.

Authors: E Lederer
Journal: J Med Chem Date: 1980-08 Impact factor: 7.446

6. Effects of sleep-promoting factor from human urine on sleep cycle of cats.

Authors: J E García-Arrarás
Journal: Am J Physiol Date: 1981-10

7. Sleep-promoting material from human urine and its relation to factor S from brain.

Authors: J M Krueger; J Bacsik; J García-Arrarás
Journal: Am J Physiol Date: 1980-02

8. Correlation between the immunoadjuvant activities and pyrogenicities of synthetic N-acetylmuramyl-peptides or -amino acids.

Authors: S Kotani; Y Watanabe; T Shimono; K Harada; T Shiba
Journal: Biken J Date: 1976-03

9. Central pyrogenic activity of muramyl dipeptide.

Authors: G Riveau; K Masek; M Parant; L Chedid
Journal: J Exp Med Date: 1980-10-01 Impact factor: 14.307

10. Effect of indomethacin on increased resistance to bacterial infection and on febrile responses induced by muramyl dipeptide.

Authors: M Parant; G Riveau; F Parant; C A Dinarello; S M Wolff; L Chedid
Journal: J Infect Dis Date: 1980-11 Impact factor: 5.226

42 in total

Review 10. Call it Worm Sleep.

Authors: Nicholas F Trojanowski; David M Raizen
Journal: Trends Neurosci Date: 2015-12-30 Impact factor: 13.837

Sleep-promoting effects of muramyl peptides.

1. Extraction of sleep-promoting factor S from cerebrospinal fluid and from brains of sleep-deprived animals.

2. "Nature's soft nurse": a sleep-promoting factor isolated from brain.

3. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives.

4. Cerebral ventricular infusions in unrestrained rats.

Review 5. Synthetic immunostimulants derived from the bacterial cell wall.

6. Effects of sleep-promoting factor from human urine on sleep cycle of cats.

7. Sleep-promoting material from human urine and its relation to factor S from brain.

8. Correlation between the immunoadjuvant activities and pyrogenicities of synthetic N-acetylmuramyl-peptides or -amino acids.

9. Central pyrogenic activity of muramyl dipeptide.

10. Effect of indomethacin on increased resistance to bacterial infection and on febrile responses induced by muramyl dipeptide.

1. TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription.

2. Sleep and immunity: A growing field with clinical impact.

3. Trace levels of peptidoglycan in serum underlie the NOD-dependent cytokine response to endoplasmic reticulum stress.

4. Somnogenic activities of synthetic lipid A.

5. Evaluation in rats of the somnogenic, pyrogenic, and central nervous system depressant effects of muramyl dipeptide.

6. A study on the rat brain receptors for tachykinins and muramyl peptides.

7. Peptidoglycan fragments decrease food intake and body weight gain in rats.

8. Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis.

9. Prostaglandin D2, a cerebral sleep-inducing substance in rats.

Review 10. Call it Worm Sleep.