Literature DB >> 6962794

New anthracyclinone metabolites from two blocked mutants of Streptomyces galilaeus MA144-M1.

H Tobe, A Yoshimoto, T Ishikura, H Naganawa, T Takeuchi, H Umezawa.   

Abstract

Two blocked mutants of the aclacinomycin-producing Streptomyces galilaeus MA144-M1 produced new anthraquinones and anthracyclinones. The mutant ANR-58 produced compounds 58A, 58B, 58C (7-deoxy-2-hydroxyaklavinone), 58D (2-hydroxyaklavinone) and 58WR. All these compounds have the 2-hydroxyl group. The mutant ANR-665 produced compounds 665A and 665B. The compounds 58A, 58B and 665A have an anthraquinone skeleton.

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Year:  1982        PMID: 6962794     DOI: 10.7164/antibiotics.35.1641

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  2 in total

1.  Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin.

Authors:  Sonia Gullón; Carlos Olano; Mohamed S Abdelfattah; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Journal:  Appl Environ Microbiol       Date:  2006-06       Impact factor: 4.792

2.  Rhodomycin analogues from Streptomyces purpurascens: isolation, characterization and biological activities.

Authors:  Sunita Holkar; Deovrat Begde; Nandita Nashikkar; Tukaram Kadam; Avinash Upadhyay
Journal:  Springerplus       Date:  2013-03-09
  2 in total

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