Literature DB >> 6962540

A potential mechanism of action of colloidal bismuth subcitrate: diffusion barrier to hydrochloric acid.

S P Lee.   

Abstract

The mode of action of colloidal bismuth subcitrate (CBS), a colloidal bismuth preparation often used in the treatment of gastroduodenal ulcers, is unknown. The precipitation characteristics of CBS were determined by titration with hydrochloric acid and gastric juice. The precipitation pH were 4.0 and 3.5 respectively. Preoperative administration of CBS resulted in a preferential accumulation of bismuth in chronic gastric ulcers as determined by tissue bismuth assays. CBS and gastric glycoprotein formed an in vitro complex which markedly retarded the migration of H+. One of the mechanisms by which CBS promotes ulcer healing is through its behaviour as a diffusion barrier to hydrochloric acid.

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Year:  1982        PMID： 6962540

Source DB:  PubMed          Journal:  Scand J Gastroenterol Suppl        ISSN： 0085-5928


  14 in total

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2.  Bismuth subsalicylate reduces peptic injury of the oesophagus in rabbits.

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Journal:  Gut       Date:  1990-01       Impact factor: 23.059

3.  Regulation of metal absorption in the gastrointestinal tract.

Authors:  M W Whitehead; R P Thompson; J J Powell
Journal:  Gut       Date:  1996-11       Impact factor: 23.059

4.  Effect of repeated colloidal bismuth subcitrate treatment on the response of the rat gastric mucosa to the presence of luminal ethanol.

Authors:  S M Hinsull; D Bellamy
Journal:  Gut       Date:  1990-04       Impact factor: 23.059

5.  Effect of bismuth subcitrate on amphibian gastroduodenal bicarbonate secretion.

Authors:  C J Shorrock; J R Crampton; L C Gibbons; W D Rees
Journal:  Gut       Date:  1989-07       Impact factor: 23.059

6.  Epidermal growth factor (EGF) in the gastroprotective and ulcer healing actions of colloidal bismuth subcitrate (De-Nol) in rats.

Authors:  S J Konturek; A Dembinski; Z Warzecha; W Bielanski; T Brzozowski; D Drozdowicz
Journal:  Gut       Date:  1988-07       Impact factor: 23.059

7.  Uptake and subcellular localisation of bismuth in the gastrointestinal mucosa of rats after short term administration of colloidal bismuth subcitrate.

Authors:  D Stiel; D J Murray; T J Peters
Journal:  Gut       Date:  1985-04       Impact factor: 23.059

8.  Chemical structure of bismuth compounds determines their gastric ulcer healing efficacy and anti-Helicobacter pylori activity.

Authors:  G S Sandha; R LeBlanc; S J Van Zanten; T D Sitland; L Agocs; N Burford; L Best; D Mahoney; P Hoffman; D J Leddin
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9.  Gastrocytoprotection by colloidal bismuth subcitrate (De-Nol) and sucralfate. Role of endogenous prostaglandins.

Authors:  S J Konturek; T Radecki; I Piastucki; T Brzozowski; D Drozdowicz
Journal:  Gut       Date:  1987-02       Impact factor: 23.059

10.  Effect of Helicobacter pylori infection on colloidal bismuth subcitrate concentration in gastric mucus.

Authors:  D J Muñoz; C Tasman-Jones; J Pybus
Journal:  Gut       Date:  1992-05       Impact factor: 23.059
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