Peripheral vasospasm during beta-receptor blockade - a comparison between metoprolol and pindolol.

Ten men reported vasospastic symptoms in their hands during metoprolol treatment. They had no signs of occlusive arterial disease. The temperature reaction to local cooling was measured and no improvement was found after changing to pindolol. Vasospastic symptoms during beta-receptor blockade may arise in predisposed individuals irrespective of the type of beta-receptor antagonist used.