Literature DB >> 6959126

A neural cell adhesion molecule from human brain.

D A McClain, G M Edelman.   

Abstract

We have used a crossreactive monoclonal antibody against a mouse neural cell adhesion molecule (N-CAM) to characterize and purify an antigen from embryonic and neonatal human brain. This antigen was identified as human N-CAM according to several criteria, including molecular weight, sialic acid content, amino acid composition, analysis of peptide fragments, reactivity with a variety of anti-CAM antibodies, and activity of the antigen in assays of cell and membrane vesicle aggregation. The findings make feasible an exploration of the possible role of N-CAM in various neurological disorders.

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Year:  1982        PMID： 6959126      PMCID： PMC347125          DOI： 10.1073/pnas.79.20.6380

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  11 in total

1.  Adhesion among neural cells of the chick embryo. II. Purification and characterization of a cell adhesion molecule from neural retina.

Authors:  J P Thiery; R Brackenbury; U Rutishauser; G M Edelman
Journal:  J Biol Chem       Date:  1977-10-10       Impact factor: 5.157

2.  Adhesion among neural cells of the chick embryo. I. An immunological assay for molecules involved in cell-cell binding.

Authors:  R Brackenbury; J P Thiery; U Rutishauser; G M Edelman
Journal:  J Biol Chem       Date:  1977-10-10       Impact factor: 5.157

3.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

4.  Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitro.

Authors:  M Grumet; U Rutishauser; G M Edelman
Journal:  Nature       Date:  1982-02-25       Impact factor: 49.962

5.  Binding properties of a cell adhesion molecule from neural tissue.

Authors:  U Rutishauser; S Hoffman; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1982-01       Impact factor: 11.205

6.  Neural cell adhesion molecules in rodent brains isolated by monoclonal antibodies with cross-species reactivity.

Authors:  C M Chuong; D A McClain; P Streit; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

7.  Antibodies to a neural cell adhesion molecule disrupt histogenesis in cultured chick retinae.

Authors:  D R Buskirk; J P Thiery; U Rutishauser; G M Edelman
Journal:  Nature       Date:  1980-06-12       Impact factor: 49.962

8.  Chemical characterization of a neural cell adhesion molecule purified from embryonic brain membranes.

Authors:  S Hoffman; B C Sorkin; P C White; R Brackenbury; R Mailhammer; U Rutishauser; B A Cunningham; G M Edelman
Journal:  J Biol Chem       Date:  1982-07-10       Impact factor: 5.157

9.  Adhesion among neural cells of the chick embryo. IV. Role of the cell surface molecule CAM in the formation of neurite bundles in cultures of spinal ganglia.

Authors:  U Rutishauser; W E Gall; G M Edelman
Journal:  J Cell Biol       Date:  1978-11       Impact factor: 10.539

10.  The enzymatic iodination of the red cell membrane.

Authors:  A L Hubbard; Z A Cohn
Journal:  J Cell Biol       Date:  1972-11       Impact factor: 10.539
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  18 in total

1.  Characterization of cDNA clones defining variant forms of human neural cell adhesion molecule N-CAM.

Authors:  J J Hemperly; J K DeGuglielmo; R A Reid
Journal:  J Mol Neurosci       Date:  1990       Impact factor: 3.444

2.  Heterogeneity of human anti-MAG IgM as revealed by their reactivity on avian embryonic tissues.

Authors:  G C Tucker; K Dellagi; C Schmitt; J C Brouet; J P Thiery
Journal:  Clin Exp Immunol       Date:  1987-02       Impact factor: 4.330

3.  Evolutionary conservation of key structures and binding functions of neural cell adhesion molecules.

Authors:  S Hoffman; C M Chuong; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1984-11       Impact factor: 11.205

4.  Cell adhesion and morphogenesis: the regulator hypothesis.

Authors:  G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1984-03       Impact factor: 11.205

5.  Early epochal maps of two different cell adhesion molecules.

Authors:  G M Edelman; W J Gallin; A Delouvée; B A Cunningham; J P Thiery
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

6.  Neural cell adhesion molecule and polysialic acid in ductular reaction: the puzzle is far from completed, but the picture is becoming more clear.

Authors:  Mario Strazzabosco; Luca Fabris
Journal:  Hepatology       Date:  2014-10-01       Impact factor: 17.425

7.  Embryonic to adult conversion of neural cell adhesion molecules in normal and staggerer mice.

Authors:  G M Edelman; C M Chuong
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

8.  Molecular topography of the neural cell adhesion molecule N-CAM: surface orientation and location of sialic acid-rich and binding regions.

Authors:  B A Cunningham; S Hoffman; U Rutishauser; J J Hemperly; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

Review 9.  Molecular mechanisms of cell adhesion in normal and transformed cells.

Authors:  R Brackenbury
Journal:  Cancer Metastasis Rev       Date:  1985       Impact factor: 9.264

10.  Characterization and isolation of ductular cells coexpressing neural cell adhesion molecule and Bcl-2 from primary cholangiopathies and ductal plate malformations.

Authors:  L Fabris; M Strazzabosco; H A Crosby; G Ballardini; S G Hubscher; D A Kelly; J M Neuberger; A J Strain; R Joplin
Journal:  Am J Pathol       Date:  2000-05       Impact factor: 4.307
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