Literature DB >> 6958337

Acute leukemia associated with the t(4;11) chromosome rearrangement: ultrastructural and immunologic characteristics.

J L Parkin, D C Arthur, C S Abramson, R W McKenna, J H Kersey, R L Heideman, R D Brunning.   

Abstract

The acute leukemia associated with the t(4;11) chromosome rearrangement is characterized by relatively consistent clinical features: occurrence primarily in young individuals, hyperleukocytosis, and poor response to therapy. This study describes the morphological, ultrastructural, and immunologic characteristics of the leukemic cells from ten patients with this type of leukemia. The morphological features of the leukemic blasts vary from lymphoid-appearing to monocytic. Ultrastructurally and cytochemically, some of the lymphoid-appearing blasts possess features of myeloid origin. The immunologic phenotype is characteristically E- SIg- CALLA- BA-1- BA-2+ HLA-DR+ and TdT+. These findings suggest that the t(4;11)-associated acute leukemia represents a proliferation of an early myeloid progenitor cell.

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Year:  1982        PMID： 6958337

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  17 in total

1.  Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: identification of 11q23 translocation breakpoints with a yeast artificial chromosome.

Authors:  J D Rowley; M O Diaz; R Espinosa; Y D Patel; E van Melle; S Ziemin; P Taillon-Miller; P Lichter; G A Evans; J H Kersey
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes.

Authors:  J J M van Dongen; L Lhermitte; S Böttcher; J Almeida; V H J van der Velden; J Flores-Montero; A Rawstron; V Asnafi; Q Lécrevisse; P Lucio; E Mejstrikova; T Szczepański; T Kalina; R de Tute; M Brüggemann; L Sedek; M Cullen; A W Langerak; A Mendonça; E Macintyre; M Martin-Ayuso; O Hrusak; M B Vidriales; A Orfao
Journal:  Leukemia       Date:  2012-05-03       Impact factor: 11.528

3.  Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product.

Authors:  P H Domer; S S Fakharzadeh; C S Chen; J Jockel; L Johansen; G A Silverman; J H Kersey; S J Korsmeyer
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-15       Impact factor: 11.205

4.  Biphenotypic leukaemia: a case of mixed T lymphoblastic and myeloblastic leukaemia.

Authors:  M A Morgan; C S Scott; J Tavares de Castro; H J Limbert; N Polli; D Catovsky; R D Pyrah; B E Roberts
Journal:  J Clin Pathol       Date:  1985-05       Impact factor: 3.411

Review 5.  Chromosome abnormalities in acute leukemia: its clinical implications and age of onset.

Authors:  R Abe; Y Shiga; T Uchida; S Kariyone
Journal:  Indian J Pediatr       Date:  1989 Nov-Dec       Impact factor: 1.967

6.  Myelodysplastic syndrome coexisting with acute lymphoblastic leukaemia.

Authors:  A N Stark; C S Scott; B Bhatt; B E Roberts
Journal:  J Clin Pathol       Date:  1986-07       Impact factor: 3.411

7.  Fluctuation of a clone 46,XX,i(7q) in bone marrow in a Fanconi anaemia.

Authors:  J L Huret; E Benz; F Guilhot; A Brizard; J Tanzer
Journal:  Hum Genet       Date:  1986-09       Impact factor: 4.132

8.  Specific translocation t(4;11) in an infant with acute lymphoblastic leukaemia of null cell type.

Authors:  J U Walther; A Wirtz; E Thiel; C Bender-Götze
Journal:  Blut       Date:  1983-10

9.  Basophils in acute myeloid leukaemia.

Authors:  C F Hoyle; P D Sherrington; P Fischer; F G Hayhoe
Journal:  J Clin Pathol       Date:  1989-08       Impact factor: 3.411

Review 10.  Tumour biological aspects of CD24, a mucin-like adhesion molecule.

Authors:  G Kristiansen; M Sammar; P Altevogt
Journal:  J Mol Histol       Date:  2004-03       Impact factor: 2.611
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